Epidemiology of Brain Aging in the Very Old

老年人脑老化的流行病学

• 批准号: 6319466
• 负责人: LON Ray WHITE
• 金额: $ 112.05万
• 依托单位: KUAKINI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6319466
• 关键词: Alzheimer's disease; Lewy body; Parkinson's disease; aging; atrophy; brain disorders; cerebrovascular disorders; clinical research; cognition disorders; cooperative study; dementia; disease /disorder proneness /risk; epidemiology; extrapyramidal disorder; functional ability; human subject; human very old age (85+); information systems; interview; longitudinal human study; neural degeneration; neuroanatomy; pathologic process; postmortem; psychological tests

We have three fundamental aims: (1) to examine relationships of structural brain characteristics determined at autopsy with clinical diagnoses, cognitive function, and motor function in the years and months prior to death, (2) to assess associations of candidate risk factors with incident mild cognitive impairment (MCI), Alzheimer's disease (AD), vascular dementia (VsD), extrapyramidal motor signs (EMS), and Parkinson's disease (PD), and (3) to estimate age-specific incidence rates for these same endpoints, extending existing estimates into the tenth decade of life. These will be accomplished by continuing operation of the Honolulu-Asia Aging Study (HAAS) through two full examination cycles, providing new cases for analysis in combination with recently identified incident cases. All accrued data and materials will be added to the existing NIA-Kuakini HAAS Archive, to be made available to collaborating scientists at the NIA and at other extramural sites, to 'facilitate preservation and future utilization of this unique resource. Our structure-function research is focused on 4 major, distinct, aging-related structural brain changes: the Alzheimer process (indicated by neurofibrillary tangles and neuritic plaques), cerebrovascular disease (infarcts and arterial wall architecture), aging-related atrophy (general and regional), and the Lewy body process (associated with nigral degeneration, PD, EMS, and cortical Lewy body disease). Each endpoint is envisioned as linked most strongly to one of these, with variable contributions from one or more of the others. The risk factor research will include: examination of factors previously identified as associated with prevalent endpoints for their associations with incident endpoints; a search for "new" risk factors using information collected between 1986-93; and evaluation of recent data from Polysomnography, tests of olfaction, and tests of reaction time as indicators of incipient or imminent AD or PD. A closely related NIA grant will support autopsy acquisition, conduct, and data management activities related to neuropathology from June 1, 2000 through May 30, 2005. NIA contract support of current HAAS operations is scheduled to end June 30, 2001.

我们有三个基本目标：(1)检查尸检确定的脑结构特征与死亡前数年和数月的临床诊断、认知功能和运动功能的关系；(2)评估候选危险因素与轻度认知障碍（MCI）、阿尔茨海默病（AD）、血管性痴呆（VsD）、锥体外系运动体征（EMS）和帕金森病（PD）的关联；(3)估计这些相同终点的年龄特异性发病率。将现有的估计延长到生命的第10个十年。檀香山-亚洲老龄化研究（HAAS）将通过两个完整的检查周期继续运作，结合最近发现的事件案例，提供新的分析案例。所有积累的数据和材料将被添加到现有的NIA- kuakini HAAS档案中，供NIA和其他校外站点的合作科学家使用，以促进这一独特资源的保存和未来利用。我们的结构-功能研究主要集中在4个主要的、不同的、与衰老相关的大脑结构变化：阿尔茨海默病（以神经原纤维缠结和神经斑块为标志）、脑血管疾病（梗死和动脉壁结构）、与衰老相关的萎缩（全身和局部）和路易体过程（与神经变性、PD、EMS和皮质路易体病相关）。每个端点都被设想为与其中一个最紧密地联系在一起，并有一个或多个其他端点的可变贡献。风险因素研究将包括：检查先前确定的与流行终点相关的因素与事件终点的关联；利用1986- 1993年收集的资料搜寻“新的”危险因素；并评估近期多导睡眠图、嗅觉测试和反应时间测试的数据，作为早期或即将发生的AD或PD的指标。从2000年6月1日至2005年5月30日，一项密切相关的NIA拨款将支持与神经病理学相关的尸检采集、实施和数据管理活动。NIA合同支持当前HAAS操作计划于2001年6月30日结束。