INBRE EVALUATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 2004年，夏威夷大学从NCRR/NIH获得了为期五年的1400万美元的奖励，这是根据IDEA Networks for Biomedical Research Experence(INBRE)计划在夏威夷发展具有竞争力的生物医学研究。这项评估涵盖了INBRE五年期奖项的第三年，并建立在NCRR/NIH资助的之前对Brin奖的评估的基础上。 今年，行政核心的所有三个关键职位，包括首席调查员的职位，都因辞职和随后的征聘困难而长期空缺。在此期间，从这个核心发出的活动很少。然而，当这三个职位最终在2006年底全部填补时，情况发生了戏剧性的变化。 夏威夷INBRE在很大程度上依赖资深科学家的非正式指导，作为在年轻研究人员中发展研究专长的一种手段。今年，和往年一样，评估人员注意到在指导方面有很大的变化。几位来自大学本科校园的初级调查员往往会遇到稀少且参差不齐的辅导。还注意到导师和S门生之间的报告存在差异。导师更有可能报告说，他们在科学活动方面提供帮助，而不是在职业发展方面。 来自夏威夷大学系统以外校区的初级调查人员也不太可能及时从INBRE收到资金。其中两名调查人员现在必须在不到三个月的时间内耗尽他们全年的资金。 外联主任在这一年的大部分时间里没有得到行政支助。也许结果是，管理旅行奖励和组织暑期学院是核心的主要活动。来自暑期学院的学生在接受跟踪调查时对工作坊给予了积极评价。根据这一反馈意见，外联主任已经开始改进下一年研究所的工作。 在花了几年时间获取必要的设备和人员后，生物信息学核心似乎已经做好了为学生和研究人员开展项目的准备。目前正在制定普及生物信息学技术的计划，正在开发本科生和研究生课程以及学位课程，在调查用户需求和提供满足这些需求的继续教育方面也取得了良好进展。 对其中一个伙伴文凭校园进行了深入的案例研究，以评估布林/INBRE基金对校园研究任务的影响。结果表明，NIH的资金通过刺激他们的科学研究计划的发展而产生了催化作用。学生入学人数、教师招聘人数、新的研究生学位项目以及科学研究基础设施的建设，都反映出该校对科学研究的兴趣与日俱增。 夏威夷经历了比美国整体更严重的NIH资金下降，从2005财年的8,450万美元下降到2006财年的5,370万美元。夏威夷在2002财年的NIH资金排名第40位，2005财年升至第35位，2006财年跌至第41位，这是自向夏威夷提供Brin/INBRE赠款以来的最低水平。 2001-2006财年的成功率数据是为新的、有竞争力的研究提案汇编的。尽管自2001年以来，获得的研究奖项数量没有大幅增加，但夏威夷研究人员提交的数量增加了一倍多。 来自非NIH来源的资金在2006财年降至7年来的最低点，为531万美元，而2004财年的高点为930万美元。与其他资金来源类似，在2005财年之前，来自其他学术机构的资金逐渐增加(330万美元)，随后在2006财年显著下降至250万美元。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In 2004, the University of Hawaii received a five-year, $14 million award from NCRR/NIH under the IDeA Networks for Biomedical Research Excellence (INBRE) program to develop competitive biomedical research in Hawaii. This evaluation covers the third year of the five-year INBRE award and builds upon the previous evaluations of the BRIN award funded by NCRR/NIH. This year all three critical positions in the administrative core, including that of the Principal Investigator, were vacant for lengthy periods of time due to resignations and subsequent recruitment difficulties. Very little activity emanated from this core during this period. This changed dramatically, however, when all three positions were finally filled at the end of 2006. The Hawaii INBRE relies heavily on informal mentoring by senior scientists as a means of developing research expertise among young researchers. This year, as in years past, the evaluators noted a great deal of variation in mentoring. Several of the Junior Investigators from baccalaureate campuses tend to experience sparse and uneven mentoring. Discrepancies in reports between mentors and the prot¿g¿s were also noted. Mentors were more likely to report that they provided assistance on scientific activities rather than on career development. Junior Investigators from campuses outside the University of Hawaii system were also less likely to have received their funds from INBRE on a timely basis. Two of the investigators must now expend their entire year of funding in less than three months. The Outreach Director had no administrative support during most of the year. Perhaps as a result, managing the travel awards and organizing the summer institute were the Cores primary activities. Students from the summer institute who responded to the follow-up survey rated the workshop positively. Based on this feedback, the Outreach Director has already initiated improvements for next years institute. After devoting several years to acquiring the necessary equipment and personnel, the Bioinformatics Core appears well-poised to carry through on programs for students and researchers. Plans to make the bioinformatics technology more widely available are underway, undergraduate and graduate courses and degree programs are being developed, and good progress is being made in surveying user needs and providing continuing education to meet those needs. An in-depth case study of one of the partner baccalaureate campuses was conducted to assess the impact of BRIN/INBRE funds on the campuss research mission. Results suggest that NIH funding has had a catalytic effect by spurring development of their scientific research program. Student enrollments, faculty hires, a new graduate degree program, and infrastructure development for scientific research reflect a growing interest in scientific research on this campus. Hawaii experienced a sharper decline in NIH funding than the U.S. as a whole, dropping from $84.5 million in FY 2005 to $53.7 million in FY 2006. Hawaii ranked 40th in NIH funding in FY 2002 and improved to 35th in FY 2005 before dropping to 41st in FY 2006, its lowest since the advent of BRIN/INBRE grants to Hawaii. Data on success rates were compiled for FY 2001 -2006 for new, competitive research proposals. Although the number of research awards received has not increased dramatically since 2001, the number of submissions from Hawaii researchers has more than doubled. Funding from non-NIH sources dipped to a seven-year low of $5.31 million in FY 2006, compared to a high of $9.3 million in FY 2004. In a pattern similar to other funding sources, there was a gradual increase in funding from other academic institutions until FY 2005 ($3.3 million), which was then followed by a pronounced drop to $2.5 million in FY 2006.