INBRE EVALUATION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 2004年，夏威夷大学获得了NCRR/NIH在IDEA生物医学研究卓越网络（INBRE）计划下的五年1400万美元的奖励，以在夏威夷开展有竞争力的生物医学研究。本次评估涵盖了为期五年的INBRE奖的第三年，并建立在由NCRR/NIH资助的BRIN奖的先前评估的基础上。 今年，由于辞职和随后的征聘困难，行政核心的所有三个关键职位，包括首席调查员的职位，都长期空缺。在此期间，该核心的活动很少。 然而，2006年底这三个职位最终都得到填补后，情况发生了巨大变化。 夏威夷的INBRE在很大程度上依赖于资深科学家的非正式指导，作为培养年轻研究人员研究专长的一种手段。与往年一样，今年的评估人员注意到辅导工作存在很大差异。来自学士学位校园的几个初级研究员往往经历稀疏和不均衡的指导。还注意到导师和学生之间的报告存在差异。导师更有可能报告说，他们提供的援助是科学活动，而不是职业发展。 来自夏威夷大学系统以外校园的初级调查员也不太可能及时从INBRE获得资金。其中两名调查人员现在必须在不到三个月的时间内花掉他们全年的资金。 外联主任在这一年的大部分时间里得不到行政支助。也许正因为如此，管理旅行奖励和组织暑期研究所是核心的主要活动。 对后续调查作出答复的暑期研究所学生对讲习班给予积极评价。根据这一反馈，外联主任已着手为明年作出改进的研究所。 经过几年的时间来获得必要的设备和人员，生物信息学核心似乎准备好进行学生和研究人员的计划。目前正在制定计划，使生物信息技术更广泛地提供，正在制定本科和研究生课程和学位课程，在调查用户需求和提供继续教育以满足这些需求方面正在取得良好进展。 对其中一个合作伙伴中学校园进行了深入的案例研究，以评估BRIN/INBRE基金对校园的影响的研究使命。结果表明，NIH的资助通过刺激其科学研究计划的发展而产生了催化作用。 学生入学，教师招聘，一个新的研究生学位课程，和基础设施的发展，科学研究反映了在这个校园里科学研究的兴趣日益增长。 夏威夷国家卫生研究院的资金比整个美国的资金下降得更快，从2005财年的8450万美元下降到2006财年的5370万美元。 夏威夷在2002财政年度的NIH资助中排名第40位，2005财政年度上升到第35位，2006财政年度下降到第41位，这是自BRIN/INBRE赠款夏威夷以来的最低水平。 数据 成功 为2001 - 2006财政年度编制了新的、有竞争力的研究提案的费率。 尽管自2001年以来，获得的研究奖项数量没有大幅增加，但来自夏威夷研究人员的投稿数量增加了一倍多。 2006财政年度，来自非NIH来源的资金下降到七年来的最低点531万美元，而2004财政年度则高达930万美元。与其他资金来源类似，其他学术机构的资金在2005财政年度之前逐渐增加（330万美元），随后在2006财政年度明显下降到250万美元。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In 2004, the University of Hawaii received a five-year, $14 million award from NCRR/NIH under the IDeA Networks for Biomedical Research Excellence (INBRE) program to develop competitive biomedical research in Hawaii. This evaluation covers the third year of the five-year INBRE award and builds upon the previous evaluations of the BRIN award funded by NCRR/NIH. This year all three critical positions in the administrative core, including that of the Principal Investigator, were vacant for lengthy periods of time due to resignations and subsequent recruitment difficulties. Very little activity emanated from this core during this period. This changed dramatically, however, when all three positions were finally filled at the end of 2006. The Hawaii INBRE relies heavily on informal mentoring by senior scientists as a means of developing research expertise among young researchers. This year, as in years past, the evaluators noted a great deal of variation in mentoring. Several of the Junior Investigators from baccalaureate campuses tend to experience sparse and uneven mentoring. Discrepancies in reports between mentors and the prot¿g¿s were also noted. Mentors were more likely to report that they provided assistance on scientific activities rather than on career development. Junior Investigators from campuses outside the University of Hawaii system were also less likely to have received their funds from INBRE on a timely basis. Two of the investigators must now expend their entire year of funding in less than three months. The Outreach Director had no administrative support during most of the year. Perhaps as a result, managing the travel awards and organizing the summer institute were the Cores primary activities. Students from the summer institute who responded to the follow-up survey rated the workshop positively. Based on this feedback, the Outreach Director has already initiated improvements for next years institute. After devoting several years to acquiring the necessary equipment and personnel, the Bioinformatics Core appears well-poised to carry through on programs for students and researchers. Plans to make the bioinformatics technology more widely available are underway, undergraduate and graduate courses and degree programs are being developed, and good progress is being made in surveying user needs and providing continuing education to meet those needs. An in-depth case study of one of the partner baccalaureate campuses was conducted to assess the impact of BRIN/INBRE funds on the campuss research mission. Results suggest that NIH funding has had a catalytic effect by spurring development of their scientific research program. Student enrollments, faculty hires, a new graduate degree program, and infrastructure development for scientific research reflect a growing interest in scientific research on this campus. Hawaii experienced a sharper decline in NIH funding than the U.S. as a whole, dropping from $84.5 million in FY 2005 to $53.7 million in FY 2006. Hawaii ranked 40th in NIH funding in FY 2002 and improved to 35th in FY 2005 before dropping to 41st in FY 2006, its lowest since the advent of BRIN/INBRE grants to Hawaii. Data on success rates were compiled for FY 2001 -2006 for new, competitive research proposals. Although the number of research awards received has not increased dramatically since 2001, the number of submissions from Hawaii researchers has more than doubled. Funding from non-NIH sources dipped to a seven-year low of $5.31 million in FY 2006, compared to a high of $9.3 million in FY 2004. In a pattern similar to other funding sources, there was a gradual increase in funding from other academic institutions until FY 2005 ($3.3 million), which was then followed by a pronounced drop to $2.5 million in FY 2006.