权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Epidemiology of Aging and Damentia - Autopsy Research

衰老和痴呆的流行病学 - 尸检研究

基本信息

批准号：
7812728
负责人：
LON Ray WHITE
金额：
$ 96.05万
依托单位：
KUAKINI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7812728
关键词：
Address Age-associated memory impairment Aged, 80 and over Aging Ally Alzheimer&apos s Disease Architecture Area Arts Atrophic Autopsy Biological Preservation Blood Blood Vessels Brain Brain region Categories Cerebellum Chronic Classification Cognitive Collaborations Complex Consultations Data Dementia Detection Deterioration Development Diagnosis Digital Photography Economics Elderly Employee Epidemiology Equipment Formalin Frequencies Frontotemporal Lobar Degenerations Funding Gliosis Grant Gray unit of radiation dose Hand Heterogeneity Hippocampus (Brain)Histologic Histopathology Human Impaired cognition Individual Infarction Inflammatory Investigation Ischemia Joints Laboratories Lesion Leukoencephalopathy Link Living Wills Luxol Fast Blue MBS Magnetic Resonance Imaging Methods Microscope Microscopic Motor Neuron Disease Neocortex Paraffin Paraffin Embedding Parents Participant Pathogenesis Pathologic Pathologic Processes Pattern Persons Phase Physical Examination Population Prevention strategy Principal Investigator Process Protocols documentation Public Health Publications Reading Recovery Research Research Personnel Resolution Risk Factors Role Sampling Sclerosis Shapes Site Slide Staging Staining method Stains Structure Temporal Lobe Testing Thick Time Tissue Sample Tissues Training U-Series Cooperative Agreements Ubiquitin United States National Institutes of Health Vascular Dementia Work aged base brain tissue comparison group design expectation gray matter insight neocortical neuron loss parent grant programs public health relevance response white matter

项目摘要

DESCRIPTION (provided by principal investigator): Our application is in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant is 5U01AG017155-08, Epidemiology of Aging and Dementia-Autopsy Research. We will address three distinct neuropathologic abnormalities found in the brains of substantial proportions of demented HAAS decedents, but that were not recognized as important causes of cognitive deterioration when the parent grant was originally designed. They are: 1) dementia lacking distinctive histopathology, 2) hippocampal sclerosis, and 3) microinfarcts. All relevant brain materials are available "wet" (in neutral formalin) or paraffin embedded. Subset panels for each of these three lesion types have been selected to minimize ambiguity related to co-morbid lesions, and for the examination of relevant comparison groups. Intensive state-of-the-art histologic methods will be applied to these panels to define their possible relationships with other known conditions (fronto-temporal dementia, motor neuron disease, chronic ischemia or chronic inflammatory states) as well as to examine possible inter-relatedness and occurrence in non-impaired decedents. Research on microinfarcts will greatly extend our understanding of optimal methods for their detection, of their distribution throughout the brain in relation to cognitive impairment, and will provide a basis for pathologic criteria for the diagnosis of "multi-microinfarct dementia" as a major category of vascular cognitive impairment. Research bearing on MRI approaches to the diagnosis of multi-microinfarct dementia during life will be carried out using brain tissues selected to be maximally informative for these purposes. The results of these efforts will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions. Major economic benefits are related to the support of new employees, increasing the level of effort of part time employees, and the purchase of essential laboratory equipment and materials needed to carry out the proposed work. PUBLIC HEALTH RELEVANCE: The results of our research will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions.

描述（由主要研究者提供）：我们的申请是为了响应NOT-OD-09-058: NIH宣布为竞争性修订申请提供恢复法案资金。父母资助为5U01AG017155-08，衰老与痴呆流行病学-尸检研究。我们将讨论三种不同的神经病理异常，这些异常在很大比例的失智HAAS死者的大脑中发现，但在最初设计父母补助金时，这些异常并没有被认为是认知退化的重要原因。它们是：1)缺乏特殊组织病理学的痴呆；2)海马硬化；3)微梗死。所有相关脑材料均可“湿”（中性福尔马林）或石蜡包埋。为这三种病变类型中的每一种选择了子集组，以尽量减少与合并症病变相关的模糊性，并对相关对照组进行检查。将对这些小组应用最先进的组织学方法，以确定它们与其他已知疾病（额颞叶痴呆、运动神经元疾病、慢性缺血或慢性炎症状态）的可能关系，并检查在未受损的死者中可能存在的相互关系和发生情况。对微梗死的研究将极大地扩展我们对其最佳检测方法的理解，以及与认知障碍相关的微梗死在整个大脑中的分布，并将为“多微梗死性痴呆”作为血管性认知障碍的主要类别的诊断提供病理标准的基础。研究与MRI方法在生命中诊断多发性微梗死性痴呆的关系，将使用脑组织进行选择，以最大限度地为这些目的提供信息。这些努力的结果将对目前有关老年痴呆症原因的概念产生重大影响，并将与制定预防战略以减轻这些可怕疾病对人类和公共健康的负担高度相关。主要的经济效益与支持新员工、提高兼职员工的努力水平、购买开展拟议工作所需的必要实验室设备和材料有关。