Epidemiology of Aging and Damentia - Autopsy Research

衰老和痴呆的流行病学 - 尸检研究

• 批准号: 7812728
• 负责人: LON Ray WHITE
• 金额: $ 96.05万
• 依托单位: KUAKINI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7812728
• 关键词: Address; Age-associated memory impairment; Aged, 80 and over; Aging; Ally; Alzheimer' s Disease; Architecture; Area; Arts; Atrophic; Autopsy; Biological Preservation; Blood; Blood Vessels; Brain; Brain region; Categories; Cerebellum; Chronic; Classification; Cognitive; Collaborations; Complex; Consultations; Data; Dementia; Detection; Deterioration; Development; Diagnosis; Digital Photography; Economics; Elderly; Employee; Epidemiology; Equipment; Formalin; Frequencies; Frontotemporal Lobar Degenerations; Funding; Gliosis; Grant; Gray unit of radiation dose; Hand; Heterogeneity; Hippocampus (Brain); Histologic; Histopathology; Human; Impaired cognition; Individual; Infarction; Inflammatory; Investigation; Ischemia; Joints; Laboratories; Lesion; Leukoencephalopathy; Link; Living Wills; Luxol Fast Blue MBS; Magnetic Resonance Imaging; Methods; Microscope; Microscopic; Motor Neuron Disease; Neocortex; Paraffin; Paraffin Embedding; Parents; Participant; Pathogenesis; Pathologic; Pathologic Processes; Pattern; Persons; Phase; Physical Examination; Population; Prevention strategy; Principal Investigator; Process; Protocols documentation; Public Health; Publications; Reading; Recovery; Research; Research Personnel; Resolution; Risk Factors; Role; Sampling; Sclerosis; Shapes; Site; Slide; Staging; Staining method; Stains; Structure; Temporal Lobe; Testing; Thick; Time; Tissue Sample; Tissues; Training; U-Series Cooperative Agreements; Ubiquitin; United States National Institutes of Health; Vascular Dementia; Work; aged; base; brain tissue; comparison group; design; expectation; gray matter; insight; neocortical; neuron loss; parent grant; programs; public health relevance; response; white matter

DESCRIPTION (provided by principal investigator): Our application is in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant is 5U01AG017155-08, Epidemiology of Aging and Dementia-Autopsy Research. We will address three distinct neuropathologic abnormalities found in the brains of substantial proportions of demented HAAS decedents, but that were not recognized as important causes of cognitive deterioration when the parent grant was originally designed. They are: 1) dementia lacking distinctive histopathology, 2) hippocampal sclerosis, and 3) microinfarcts. All relevant brain materials are available "wet" (in neutral formalin) or paraffin embedded. Subset panels for each of these three lesion types have been selected to minimize ambiguity related to co-morbid lesions, and for the examination of relevant comparison groups. Intensive state-of-the-art histologic methods will be applied to these panels to define their possible relationships with other known conditions (fronto-temporal dementia, motor neuron disease, chronic ischemia or chronic inflammatory states) as well as to examine possible inter-relatedness and occurrence in non-impaired decedents. Research on microinfarcts will greatly extend our understanding of optimal methods for their detection, of their distribution throughout the brain in relation to cognitive impairment, and will provide a basis for pathologic criteria for the diagnosis of "multi-microinfarct dementia" as a major category of vascular cognitive impairment. Research bearing on MRI approaches to the diagnosis of multi-microinfarct dementia during life will be carried out using brain tissues selected to be maximally informative for these purposes. The results of these efforts will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions. Major economic benefits are related to the support of new employees, increasing the level of effort of part time employees, and the purchase of essential laboratory equipment and materials needed to carry out the proposed work. PUBLIC HEALTH RELEVANCE: The results of our research will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions.

描述(由首席调查员提供)：我们的申请是对NOT-OD-09-058的回应：NIH宣布为竞争性修订申请提供恢复法案资金。家长资助为5U01AG017155-08，老龄化和痴呆症流行病学-尸检研究。我们将解决在相当大比例的痴呆症患者的大脑中发现的三种明显的神经病理异常，但在最初设计父母赠款时，这些异常并未被认为是认知恶化的重要原因。它们是：1)缺乏独特组织病理学的痴呆，2)海马区硬化，3)微梗塞。所有相关的脑材料都是“湿”的(中性福尔马林)或石蜡包埋的。选择了这三种病变类型的子集面板，以最大限度地减少与合并病变相关的模糊性，并用于相关对照组的检查。密集的最先进的组织学方法将被应用于这些小组，以确定它们与其他已知疾病(额颞性痴呆、运动神经元病、慢性缺血或慢性炎症状态)的可能关系，并检查可能的相互关联和在非受损死者中的发生。对微梗塞的研究将极大地扩展我们对其最佳检测方法的理解，了解其在大脑中的分布与认知障碍的关系，并将为诊断作为一种主要类型的血管性认知障碍的多微梗死性痴呆的病理标准提供基础。将使用为这些目的选择信息量最大的脑组织进行与MRI方法有关的研究，以诊断生活中的多发性微梗死性痴呆症。这些努力的结果将对目前有关晚年痴呆症原因的概念产生重大影响，并将与制定预防战略以减少这些可怕疾病造成的人类和公共卫生负担高度相关。主要经济利益与支持新员工、增加兼职员工的工作水平以及购买开展拟议工作所需的必要实验室设备和材料有关。 公共卫生相关性：我们的研究结果将对目前与晚年痴呆症病因相关的概念产生重大影响，并将与制定预防战略以减少这些可怕疾病造成的人类和公共卫生负担高度相关。