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Epidemiology of Aging and Damentia - Autopsy Research

衰老和痴呆的流行病学 - 尸检研究

基本信息

批准号：
7812728
负责人：
LON Ray WHITE
金额：
$ 96.05万
依托单位：
KUAKINI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7812728
关键词：
Address Age-associated memory impairment Aged, 80 and over Aging Ally Alzheimer&apos s Disease Architecture Area Arts Atrophic Autopsy Biological Preservation Blood Blood Vessels Brain Brain region Categories Cerebellum Chronic Classification Cognitive Collaborations Complex Consultations Data Dementia Detection Deterioration Development Diagnosis Digital Photography Economics Elderly Employee Epidemiology Equipment Formalin Frequencies Frontotemporal Lobar Degenerations Funding Gliosis Grant Gray unit of radiation dose Hand Heterogeneity Hippocampus (Brain)Histologic Histopathology Human Impaired cognition Individual Infarction Inflammatory Investigation Ischemia Joints Laboratories Lesion Leukoencephalopathy Link Living Wills Luxol Fast Blue MBS Magnetic Resonance Imaging Methods Microscope Microscopic Motor Neuron Disease Neocortex Paraffin Paraffin Embedding Parents Participant Pathogenesis Pathologic Pathologic Processes Pattern Persons Phase Physical Examination Population Prevention strategy Principal Investigator Process Protocols documentation Public Health Publications Reading Recovery Research Research Personnel Resolution Risk Factors Role Sampling Sclerosis Shapes Site Slide Staging Staining method Stains Structure Temporal Lobe Testing Thick Time Tissue Sample Tissues Training U-Series Cooperative Agreements Ubiquitin United States National Institutes of Health Vascular Dementia Work aged base brain tissue comparison group design expectation gray matter insight neocortical neuron loss parent grant programs public health relevance response white matter

项目摘要

DESCRIPTION (provided by principal investigator): Our application is in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant is 5U01AG017155-08, Epidemiology of Aging and Dementia-Autopsy Research. We will address three distinct neuropathologic abnormalities found in the brains of substantial proportions of demented HAAS decedents, but that were not recognized as important causes of cognitive deterioration when the parent grant was originally designed. They are: 1) dementia lacking distinctive histopathology, 2) hippocampal sclerosis, and 3) microinfarcts. All relevant brain materials are available "wet" (in neutral formalin) or paraffin embedded. Subset panels for each of these three lesion types have been selected to minimize ambiguity related to co-morbid lesions, and for the examination of relevant comparison groups. Intensive state-of-the-art histologic methods will be applied to these panels to define their possible relationships with other known conditions (fronto-temporal dementia, motor neuron disease, chronic ischemia or chronic inflammatory states) as well as to examine possible inter-relatedness and occurrence in non-impaired decedents. Research on microinfarcts will greatly extend our understanding of optimal methods for their detection, of their distribution throughout the brain in relation to cognitive impairment, and will provide a basis for pathologic criteria for the diagnosis of "multi-microinfarct dementia" as a major category of vascular cognitive impairment. Research bearing on MRI approaches to the diagnosis of multi-microinfarct dementia during life will be carried out using brain tissues selected to be maximally informative for these purposes. The results of these efforts will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions. Major economic benefits are related to the support of new employees, increasing the level of effort of part time employees, and the purchase of essential laboratory equipment and materials needed to carry out the proposed work. PUBLIC HEALTH RELEVANCE: The results of our research will have a major impact on current concepts related to the causes of dementia in late life, and will be highly relevant to the development of preventive strategies to reduce the human and public health burden of these terrible afflictions.

描述（由主要研究者提供）：我们的申请是对NOT-OD-09-058的回应：NIH宣布为竞争性修订申请提供恢复法案资金。母基金是5 U 01 AG 017155 -08，衰老和痴呆症的流行病学-尸检研究。我们将讨论三个不同的神经病理异常发现在大脑中的痴呆哈斯死者的相当大的比例，但没有被认为是重要的原因，认知能力下降时，父母补助金最初的设计。它们是：1）缺乏独特组织病理学的痴呆症，2）海马硬化症，和3）微梗塞。所有相关的脑组织材料都是“湿的”（中性福尔马林）或石蜡包埋的。选择这三种病变类型的子集，以尽量减少与共病病变相关的模糊性，并检查相关的比较组。将对这些组应用最先进的组织学方法，以确定其与其他已知疾病（额颞叶痴呆、运动神经元疾病、慢性缺血或慢性炎症状态）的可能关系，并检查可能的相互关系和在非受损死亡动物中的发生率。对微梗塞的研究将极大地扩展我们对其检测的最佳方法的理解，其在整个大脑中的分布与认知障碍的关系，并将为诊断作为血管性认知障碍的主要类别的“多微梗塞性痴呆”的病理标准提供基础。将使用为这些目的选择的最大信息量的脑组织进行关于MRI方法诊断生活中多发性微梗塞性痴呆的研究。这些努力的结果将对目前有关老年痴呆症原因的概念产生重大影响，并将与制定预防战略以减少这些可怕的痛苦对人类和公共卫生的负担高度相关。主要的经济效益与新雇员的支持、增加兼职雇员的努力水平以及购买开展拟议工作所需的基本实验室设备和材料有关。公共卫生关系：我们的研究结果将对与老年痴呆症原因相关的当前概念产生重大影响，并将与制定预防战略以减少这些可怕的痛苦的人类和公共卫生负担高度相关。