MECHANISM & POTENTIAL OF RETINOID & DNA DAMAGE THERAPY

机制

• 批准号: 6376741
• 负责人: DORIS Mangiaracina BENBROOK
• 金额: $ 14.34万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376741
• 关键词: DNA damage; antisense nucleic acid; apoptosis; athymic mouse; cell growth regulation; cell line; cervix neoplasms; cis platinum compound; combination cancer therapy; flow cytometry; metastasis; neoplasm /cancer nutrition therapy; neoplasm /cancer radiation therapy; neoplasm /cancer transplantation; nutrition related tag; ovary neoplasms; p53 gene /protein; retinoid binding proteins; retinoids

项目成果

Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.

视黄酸使宫颈癌细胞系对低剂量辐射敏感不需要功能性 p53。

• DOI: 10.1016/j.ygyno.2004.12.034
• 发表时间: 2005
• 期刊: Gynecologic oncology
• 影响因子: 4.7
• 作者: Tillmanns,ToddD;Kamelle,ScottA;Guruswamy,Suresh;Gould,NatalieS;Rutledge,TeresaL;Benbrook,DorisM
• 通讯作者: Benbrook,DorisM

Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro.

类视黄醇在体外增强宫颈癌细胞中基于顺铂的放化疗。

• DOI: 10.1006/gyno.2002.6590
• 发表时间: 2002
• 期刊: Gynecologic oncology
• 影响因子: 4.7
• 作者: ScribnerJr,DennisR;Benbrook,DorisM
• 通讯作者: Benbrook,DorisM