ANTHRAX MOLECULAR EVOLUTION, DIVERSITY AND EPIDEMIOLOGY

炭疽分子进化、多样性和流行病学

• 批准号: 6387095
• 负责人: Paul Stephen Keim
• 金额: $ 28.29万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6387095
• 关键词: RNase protection assay; alleles; anthrax; bacterial genetics; biochemical evolution; computer simulation; disease outbreaks; ecology; gene expression; gene mutation; genetic markers; genetic polymorphism; geographic site; host organism interaction; linkage mapping; mathematical model; microorganism classification; molecular genetics; northern blottings; nucleic acid repetitive sequence

DESCRIPTION (Adapted from the Applicant's Abstract): The overall goal of this study is to link the molecular genetic evolution of Bacillus anthracis to epidemiological models of North American and African anthrax in an effort to better understand the geographic, biotic, and abiotic conditions responsible for outbreaks of anthrax in the world at large and the sources of this pathogen. Towards this end, Dr. Keim and his collaborators will: (1) study the genetic-molecular epidemiology of Bacillus anthracis isolated from different geographic locations and habitats, (2) ascertain the different factors (parameters) that affect the distribution of the molecular markers they employ in their epidemiology surveys and estimate the values of these parameters in laboratory culture. (3) Using Monte Carlo simulations, they will ascertain how the distribution of these markers within and between populations of Bacillus anthracis will be affected by geographic, genetic and ecological processes.

描述（改编自申请人的摘要）：本发明的总体目标是： 这项研究的目的是将炭疽杆菌的分子遗传进化与 北美和非洲炭疽的流行病学模型， 更好地了解地理、生物和非生物条件 炭疽病在世界各地的爆发和它的来源 病原体为此，Keim博士及其合作者将：（1）研究 炭疽杆菌的遗传-分子流行病学研究 不同的地理位置和栖息地，（2）确定不同的 影响分子标记分布的因素（参数） 他们在流行病学调查中使用， 实验室培养中的参数。(3)使用蒙特卡罗模拟，他们将 确定这些标记在内部和之间的分布 炭疽杆菌的种群将受到地理、遗传和 生态过程