IRON AND IMMUNE DEFENSE IN INSECTS

昆虫的铁和免疫防御

• 批准号: 6343096
• 负责人: JOHN H LAW
• 金额: $ 20.21万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6343096
• 关键词: Aedes; Diptera; Drosophilidae; Insecta; bactericidal immunity; binding proteins; ferritin; gene expression; immunity; in situ hybridization; iron metabolism; molecular cloning; northern blottings; protein biosynthesis; protein structure; structural genes; transferrin

DESCRIPTION (Adapted from the Applicant's Abstract): Iron is an essential nutrient for nearly all life forms. It is also a dangerous toxin that must be controlled in biological systems. Proeins that have a high affinity for binding ionic iron or are capable of sequestering it so that it cannot exhibit its harmful effects are produced by virtually all organisms. These same proteins sometimes are used as a defense against parasites and pathogens by depriving them of a nutrient source of iron. The use of the iron-binding proteins transferrin and ferritin as a protection against iron poisoning or defense against pathogens and parasites will be investigated in flies and mosquitoes. It is known the transferrin synthesis is increased by bacterial infection of these insects. This is a part of the insect innate immune system.

描述（改编自申请人摘要）：铁是一种必需元素