IRON AND IMMUNE DEFENSE IN INSECTS

昆虫的铁和免疫防御

• 批准号: 6490219
• 负责人: JOHN H LAW
• 金额: $ 20.68万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6490219
• 关键词: Aedes; Diptera; Drosophilidae; Insecta; bactericidal immunity; binding proteins; ferritin; gene expression; immunity; in situ hybridization; iron metabolism; molecular cloning; northern blottings; protein biosynthesis; protein structure; structural genes; transferrin

DESCRIPTION (Adapted from the Applicant's Abstract): Iron is an essential nutrient for nearly all life forms. It is also a dangerous toxin that must be controlled in biological systems. Proeins that have a high affinity for binding ionic iron or are capable of sequestering it so that it cannot exhibit its harmful effects are produced by virtually all organisms. These same proteins sometimes are used as a defense against parasites and pathogens by depriving them of a nutrient source of iron. The use of the iron-binding proteins transferrin and ferritin as a protection against iron poisoning or defense against pathogens and parasites will be investigated in flies and mosquitoes. It is known the transferrin synthesis is increased by bacterial infection of these insects. This is a part of the insect innate immune system.

描述(改编自申请者摘要)：铁是必需的 几乎所有生命形式都需要营养。它也是一种危险的毒素，必须 在生物系统中控制的。结合亲和力高的蛋白 离子铁或能够隔离它，使其不能表现出它的 几乎所有的生物都会产生有害的影响。这些相同的蛋白质 有时被用来防御寄生虫和病原体通过剥夺 它们是铁的营养来源。铁结合蛋白的应用 转铁蛋白和铁蛋白作为铁中毒或防御的保护 针对病原体和寄生虫的研究将在苍蝇和蚊子身上进行。 已知转铁蛋白的合成是由细菌感染引起的。 这些昆虫。这是昆虫先天免疫系统的一部分。