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CALCIUM REGULATION OF SECRETION IN NEUROENDOCRINE CELLS

CALCIUM REGULATION OF SECRETION IN NEUROENDOCRINE CELLS
神经内分泌细胞钙分泌的调节
批准号:
6177062
负责人:
THOMAS F. J. MARTIN
金额:
$21.18万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-06-10 至 2002-03-31

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英文摘要
DESCRIPTION: Based on preliminary results the P.I. has proposed an interesting and reasonable central hypothesis, that CAPS acts on membranes to facilitate membrane interactions or fusion by interacting with PIP2. The P.I. proposes to test this hypothesis by addressing four specific aims. The goal of specific aim 1 is to characterize the mechanism of CAPS action. The goal of specific aim 2 is to begin to analyze the structure of CAPS and to investigate conformational changes in CAPS upon binding to PIP2. The goal of specific aim 3 is to characterize the CAPS null phenotype in neural cells. The goal of specific aim 4 is to characterize a new cytosolic factor that may be involved in triggering fusion.
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Calcium regulation of secretion in neuroendocrine cells
  • 批准号:
    7991652
  • 项目类别:
  • 资助金额:
    $3.79万
  • 财政年份:
    2009
  • 负责人:
    THOMAS F. J. MARTIN
  • 依托单位:
CELL BIOLOGY OF THE NEURON GORDON RESEARCH CONFERENCE
  • 批准号:
    6197096
  • 项目类别:
  • 资助金额:
    $4.8万
  • 财政年份:
    2000
  • 负责人:
    THOMAS F. J. MARTIN
  • 依托单位:
Calcium regulation of secretion in neuroendocrine cells
  • 批准号:
    6475197
  • 项目类别:
  • 资助金额:
    $33.73万
  • 财政年份:
    1998
  • 负责人:
    THOMAS F. J. MARTIN
  • 依托单位:
Calcium regulation of secretion in neuroendocrine cells
  • 批准号:
    7404396
  • 项目类别:
  • 资助金额:
    $29.17万
  • 财政年份:
    1998
  • 负责人:
    THOMAS F. J. MARTIN
  • 依托单位:
海外基金