METABOLIC CORE

代谢核心

• 批准号: 7638638
• 负责人: OWEN P MCGUINNESS
• 金额: $ 26.7万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7638638
• 关键词: Animals; Arts; Attention; Bioluminescence; Caring; Cells; Conscious; Data; Eating; Endocrine; Energy Metabolism; Environment; Event; Exercise; Experimental Designs; Fluorescence; Fluorescence Microscopy; Fluorescent Probes; Functional disorder; Gene Expression; Health; Image; Imaging Techniques; In Vitro; Insulin; Islets of Langerhans; Kinetics; Life; Liquid substance; MFC; Metabolic; Metabolism; Methods; Microscopic; Microscopy; Monitor; Mus; Operative Surgical Procedures; Organ; Organism; Perfusion; Photons; Postoperative Period; Procedures; Process; Range; Recovery; Regulation; Research Personnel; Resources; Rest; Services; Specimen; System; Techniques; Technology; Temperature; Thick; Time; Tissues; Vertebrates; biological research; cost effective; energy balance; in vivo; insulin secretion; investigator training; islet; metabolic abnormality assessment; method development; multi-photon; optical imaging; pancreatic islet function; restraint

Section V. Metabolic Pathophysiology Core (MFC) The MFC is divided into three subcores: Metabolic Regulation, Islet Isolation, and Tissue and In Vivo Imaging. The Metabolic Regulation Subcore uses state-of-the-art techniques to assess metabolism and energy balance in the conscious mouse or perfused organ. The Islet Isolation Subcore provides high quality islets to investigators and characterizes pancreatic islet function in vitro. The Tissue and In vivo Imaging Subcore provides sensitive optical imaging techniques to monitor in vivo real time kinetics of a metabolic process or to monitor the kinetics of gene expression in vivo. Details of animal procedures can be found in "Vertebrate Animals" located at the end of the core description.

第五节代谢病理生理学核心（MFC） MFC 分为三个子核心：代谢调节、胰岛隔离以及组织和体内 成像。代谢调节子核心使用最先进的技术来评估新陈代谢和能量 有意识的小鼠或灌注器官的平衡。胰岛隔离子核心提供高质量的胰岛 研究人员并在体外表征胰岛功能。组织和体内成像子核心 提供灵敏的光学成像技术来监测体内代谢过程的实时动力学或 监测体内基因表达的动力学。动物程序的详细信息可以在“脊椎动物 动物”位于核心描述的末尾。