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REGULATION OF TESTICULAR INHIBIN/ACTIVIN GENE EXPRESSION

REGULATION OF TESTICULAR INHIBIN/ACTIVIN GENE EXPRESSION
睾丸抑制素/激活素基因表达的调节
批准号:
6176354
负责人:
CHING-LING C CHEN
金额:
$17.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-01 至 2001-06-30

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中文摘要
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英文摘要
DESCRIPTION (Adapted from the applicant's abstract): The goal of this research is to study the molecular mechanisms involved in controlling testicular physiology and male reproduction. Aim 1 will investigate the control of transcription of the rat inhibin a-subunit gene by GATA-binding proteins in MA-10 cells and rat Sertoli and Leydig cells, and will identify cofactors and cell-specific proteins that interact with GATA-1 to regulate the a-subunit gene. Aim 2 is to investigate the regulation of two promoters within the rat bB-subunit gene that give rise to two species (4.8- and 3.7-kb) of the bB-subunit mRNA from alternate initiation sites. Aim 3 will investigate the developmental expression and hormonal regulation of GATA-binding proteins in the rat testis to determine whether any observed changes correlate to the known regulation of the a- and bB-subunit genes.
期刊论文(16)
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会议论文
Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells.
促性腺激素通过 cAMP 负向调节睾丸细胞中的 GATA-1 基因表达。
DOI: 10.1210/endo.143.3.8688
发表时间: 2002
期刊: Endocrinology.
影响因子: --
作者: [Zhang,Zhifang, Wu,AiZhen, Feng,Zong-Ming, Mruk,Dolores, Cheng,CYan, Chen,Ching-LingC]
通讯作者: Chen,Ching-LingC
Immunostainable inhibin subunits are in multiple types of testicular cells.
免疫染色的抑制素亚基存在于多种类型的睾丸细胞中。
DOI: 10.1210/endo-125-4-1941
发表时间: 1989
期刊: Endocrinology
影响因子: 4.8
作者: [Shaha,C, Morris,PL, Chen,CL, Vale,W, Bardin,CW]
通讯作者: Bardin,CW
Inhibin structure and function in the testis.
睾丸中抑制素的结构和功能。
DOI: 10.1111/j.1749-6632.1989.tb25884.x
发表时间: 1989
期刊: Annals of the New York Academy of Sciences
影响因子: 5.2
作者: [Bardin,CW, Morris,PL, Shaha,C, Feng,ZM, Rossi,V, Vaughan,J, Vale,WW, Voglmayr,J, Chen,CL]
通讯作者: Chen,CL
Immunization of rams against human recombinant inhibin alpha-subunit delays, augments, and extends season-related increase in blood gonadotropin levels.
公羊针对人重组抑制素α亚基的免疫延迟、增强和延长了血液促性腺激素水平与季节相关的增加。
DOI: 10.1095/biolreprod42.1.81
发表时间: 1990
期刊: Biology of reproduction
影响因子: 3.6
作者: [Voglmayr,JK, Mizumachi,M, Washington,DW, Chen,CL, Bardin,CW]
通讯作者: Bardin,CW
15
    GATA-BINDING PROTEINS REGULATE TESTICULAR GENE EXPRESSION
    • 批准号:
      6440516
    • 项目类别:
    • 资助金额:
      $17.42万
    • 财政年份:
      2001
    • 负责人:
      CHING-LING C CHEN
    • 依托单位:
    GATA-BINDING PROTEINS REGULATE TESTICULAR GENE EXPRESSION
    • 批准号:
      6344931
    • 项目类别:
    • 资助金额:
      $23.88万
    • 财政年份:
      2000
    • 负责人:
      CHING-LING C CHEN
    • 依托单位:
    GATA-BINDING PROTEINS REGULATE TESTICULAR GENE EXPRESSION
    • 批准号:
      6301877
    • 项目类别:
    • 资助金额:
      $23.88万
    • 财政年份:
      1999
    • 负责人:
      CHING-LING C CHEN
    • 依托单位:
    GATA-BINDING PROTEINS REGULATE TESTICULAR GENE EXPRESSION
    • 批准号:
      6108355
    • 项目类别:
    • 资助金额:
      $23.88万
    • 财政年份:
      1999
    • 负责人:
      CHING-LING C CHEN
    • 依托单位:
    国内基金
    海外基金
    MTA2在睾丸支持细胞(Sertoli cells)中的功能和机制研究