BIOMECHANICS OF FOOT/ANKLE INJURIES USING 3D IMAGING

使用 3D 成像研究足部/踝部损伤的生物力学

• 批准号: 6127346
• 负责人: JAYARAM K UDUPA
• 金额: $ 30.97万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-04 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6127346
• 关键词: ankle; bioimaging /biomedical imaging; biomechanics; clinical research; foot; human subject; joint ligament; magnetic resonance imaging; method development; musculoskeletal disorder diagnosis; musculoskeletal imaging /visualization /scanning; musculoskeletal injury

DESCRIPTION (Adapted from the Applicant's Abstract): The broad goal of this research is to apply advanced imaging techniques to develop, in a patient-specific manner, a quantitative understanding of how the joints function, and of how they are affected by soft-tissue injuries and by their surgical treatment. The central hypothesis is that this understanding will lead to reliable, early and improved diagnostic and therapeutic procedures for joint ailments involving soft-tissue injuries. The focus of this proposal is on the ankle joint and its ligament injuries. The Specific Aims are: (1) to investigate ankle flexibility characteristics associated with specific ligament injuries; (2) to determine relative internal bone movements at the ankle and subtalar joints associated with ligament injuries; (3) to develop stress radiography and stress slice MRI that are optimum to show bone displacements associated with specific ligament injuries; and (4) to objectively assess the stabilization achieved by surgical reconstruction techniques for treating ligament damage. To fulfill Aim 1, a special mechanical device will be built and flexibility data will be gathered from normal injured, and post-surgical joints. To fulfill Aim 2, methods of MRI imaging under stress, image segmentation, 3-D reconstruction, and 3-D analysis will be developed. The resulting injury-specific internal displacement data will be utilized to devise simple, cost-effective methods, such as stress radiography and stress slice MRI, that best show the effect of injury (Aim 3). Such data will be used to objectively assess surgical reconstruction techniques based on pre- and post-operative scans and measurements (Aim 4). The expected outcomes of this research are twofold: (1) simple, cost-effective and high specificity methods of diagnosing ankle ligament injuries; and (2) new knowledge about the exact displacements occurring at the ankle and subtalar joints as a result of ligament injuries or their surgical repair.

描述（改编自申请人的摘要）：此的广泛目标 研究是应用高级成像技术来开发 特定于患者的方式，对关节的定量理解 功能，以及如何受到软组织伤害的影响 手术治疗。中心假设是这种理解将领导 可靠，早期和改进的联合诊断和治疗程序 涉及软组织伤害的疾病。该提议的重点是 踝关节及其韧带受伤。具体目的是：（1） 研究与特定韧带相关的踝关节柔韧性特征 受伤； （2）确定踝关节的相对内部骨运动 与韧带损伤有关的下关节； （3）发展压力 放射线照相和应力切片MRI，最适合显示骨位移 与特定的韧带损伤有关； （4）客观地评估 通过手术重建技术实现的稳定 韧带损伤。为了实现AIM 1，将建造一种特殊的机械设备 灵活性数据将从正常受伤和手术后收集 关节。为了实现AIM 2，在压力下的MRI成像方法，图像 将开发分割，3-D重建和3-D分析。这 最终的特定伤害的内部位移数据将用于设计 简单，成本效益的方法，例如应力射线照相和应力切片 MRI，最好显示受伤的影响（AIM 3）。这样的数据将用于 基于前和 术后扫描和测量值（AIM 4）。预期的结果 研究是双重的：（1）简单，成本效益和高特异性方法 诊断踝韧带损伤； （2）有关确切的新知识 由于踝关节和下关节的位移 韧带损伤或手术修复。