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BIOMECHANICS OF FOOT/ANKLE INJURIES USING 3D IMAGING

使用 3D 成像研究足部/踝部损伤的生物力学

基本信息

批准号：
6512245
负责人：
JAYARAM K UDUPA
金额：
$ 28.9万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-04 至 2004-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6512245
关键词：
ankle bioimaging /biomedical imaging biomechanics clinical research foot human subject joint ligament magnetic resonance imaging method development musculoskeletal disorder diagnosis musculoskeletal imaging /visualization /scanning musculoskeletal injury

项目摘要

DESCRIPTION (Adapted from the Applicant's Abstract): The broad goal of this research is to apply advanced imaging techniques to develop, in a patient-specific manner, a quantitative understanding of how the joints function, and of how they are affected by soft-tissue injuries and by their surgical treatment. The central hypothesis is that this understanding will lead to reliable, early and improved diagnostic and therapeutic procedures for joint ailments involving soft-tissue injuries. The focus of this proposal is on the ankle joint and its ligament injuries. The Specific Aims are: (1) to investigate ankle flexibility characteristics associated with specific ligament injuries; (2) to determine relative internal bone movements at the ankle and subtalar joints associated with ligament injuries; (3) to develop stress radiography and stress slice MRI that are optimum to show bone displacements associated with specific ligament injuries; and (4) to objectively assess the stabilization achieved by surgical reconstruction techniques for treating ligament damage. To fulfill Aim 1, a special mechanical device will be built and flexibility data will be gathered from normal injured, and post-surgical joints. To fulfill Aim 2, methods of MRI imaging under stress, image segmentation, 3-D reconstruction, and 3-D analysis will be developed. The resulting injury-specific internal displacement data will be utilized to devise simple, cost-effective methods, such as stress radiography and stress slice MRI, that best show the effect of injury (Aim 3). Such data will be used to objectively assess surgical reconstruction techniques based on pre- and post-operative scans and measurements (Aim 4). The expected outcomes of this research are twofold: (1) simple, cost-effective and high specificity methods of diagnosing ankle ligament injuries; and (2) new knowledge about the exact displacements occurring at the ankle and subtalar joints as a result of ligament injuries or their surgical repair.

描述（改编自申请人的摘要）：本发明的广泛目标是：研究是应用先进的成像技术，患者特异性方式，定量了解关节如何功能，以及它们如何受到软组织损伤的影响，手术治疗核心假设是，这种理解将导致可靠、早期和改进的关节炎诊断和治疗程序包括软组织损伤的疾病。本提案的重点是踝关节及其韧带损伤。具体目标是：（1）踝关节特异性韧带柔韧性研究损伤;（2）确定踝关节的相对内部骨骼运动，距下关节韧带损伤;（3）产生应力最适合显示骨移位的X线摄影和应力切片MRI 与特定韧带损伤相关;（4）客观评估通过外科重建技术实现稳定，韧带损伤为了实现目标1，将建造一个特殊的机械装置和灵活性数据将收集从正常受伤，接头.为了实现目标2，应力下MRI成像的方法，将开发分割、三维重建和三维分析。的将利用由此产生的具体伤害的国内流离失所数据，简单、成本效益高的方法，如应力射线照相和应力切片 MRI，最能显示损伤的影响（目的3）。这些数据将用于客观评估手术重建技术的基础上，术后扫描和测量（目标4）。预期的结果研究主要有两个方面：（1）简单、经济、特异性高的方法诊断踝关节韧带损伤;和（2）关于确切的新知识在踝关节和距下关节发生的位移，韧带损伤或手术修复。