BIOMECHANICS OF FOOT/ANKLE INJURIES USING 3D IMAGING

描述(改编自申请人的摘要)：本报告的总体目标 研究是应用先进的成像技术来开发，在一个 针对患者的具体情况，定量了解关节如何 功能，以及他们如何受到软组织损伤和他们的 外科治疗。中心假设是，这种理解将导致 到可靠、早期和改进的关节诊断和治疗程序 涉及软组织损伤的疾病。这项提案的重点是 踝关节及其韧带损伤。具体目标是：(1) 研究与特定韧带相关的踝关节柔韧性特征 损伤；(2)确定踝关节和 距下关节与韧带损伤相关；(3)产生压力 最能显示骨骼移位的X线片和应力切片MRI 与特定韧带损伤相关；以及(4)客观评估 外科重建技术在治疗中实现的稳定 韧带损伤。为了实现目标1，将建造一种特殊的机械装置 柔韧性数据将从正常受伤的人和手术后收集 关节。为实现目标2，应激状态下的磁共振成像方法， 将开发分割、三维重建和三维分析。这个 由此产生的特定于伤害的内部位移数据将被用于设计 简单、成本效益高的方法，如应力射线照相术和应力切片 MRI，最能显示损伤效果(目标3)。这些数据将被用来 根据Pre和Pre-and客观评估外科重建技术 术后扫描和测量(目标4)。这样做的预期结果是 研究有两个方面：(1)简单、经济有效和高特异性的方法 对踝关节韧带损伤的诊断；以及(2)对准确的 在踝关节和距下关节发生的移位是由 韧带损伤或手术修复。

DESCRIPTION (Adapted from the Applicant's Abstract): The broad goal of this research is to apply advanced imaging techniques to develop, in a patient-specific manner, a quantitative understanding of how the joints function, and of how they are affected by soft-tissue injuries and by their surgical treatment. The central hypothesis is that this understanding will lead to reliable, early and improved diagnostic and therapeutic procedures for joint ailments involving soft-tissue injuries. The focus of this proposal is on the ankle joint and its ligament injuries. The Specific Aims are: (1) to investigate ankle flexibility characteristics associated with specific ligament injuries; (2) to determine relative internal bone movements at the ankle and subtalar joints associated with ligament injuries; (3) to develop stress radiography and stress slice MRI that are optimum to show bone displacements associated with specific ligament injuries; and (4) to objectively assess the stabilization achieved by surgical reconstruction techniques for treating ligament damage. To fulfill Aim 1, a special mechanical device will be built and flexibility data will be gathered from normal injured, and post-surgical joints. To fulfill Aim 2, methods of MRI imaging under stress, image segmentation, 3-D reconstruction, and 3-D analysis will be developed. The resulting injury-specific internal displacement data will be utilized to devise simple, cost-effective methods, such as stress radiography and stress slice MRI, that best show the effect of injury (Aim 3). Such data will be used to objectively assess surgical reconstruction techniques based on pre- and post-operative scans and measurements (Aim 4). The expected outcomes of this research are twofold: (1) simple, cost-effective and high specificity methods of diagnosing ankle ligament injuries; and (2) new knowledge about the exact displacements occurring at the ankle and subtalar joints as a result of ligament injuries or their surgical repair.