NOVEL MECHANISMS REGULATING NITRIC OXIDE IN THE SKIN

调节皮肤中一氧化氮的新机制

• 批准号: 6346158
• 负责人: JEFFREY D LASKIN
• 金额: $ 13.47万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6346158
• 关键词: G protein; biosynthesis; immunocytochemistry; in situ hybridization; interferon gamma; keratinocyte; laboratory mouse; nitric oxide; nitric oxide synthase; phorbols; physical chemical interaction; protein isoforms; ultraviolet radiation

Studies are proposed in this application to study N0S isoform expression in keratinocytes and the mechanisms by which G proteins control N0 production in the skin. The primary hypothesis to be tested is that G proteins participate in the regulation of N0 biosynthesis in keratinocytes following cytokine challenge or toxic injury.

在本申请中提出了研究NOS同种型的研究 G蛋白在角质形成细胞中的表达以及G蛋白 控制皮肤中NO的产生。 主要假设是 G蛋白参与了N0的调节 在细胞因子攻击或毒性后角质形成细胞的生物合成 损伤