TOXICOLOGY MODULE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Toxicology has been identified as thematic area where the tools and expertise developed by the BioCurrents group could find powerful applications. To further that goal a research module was formed, coordinated by Jeffrey Laskin of UMDNJ and Rutgers University. His particular area of interest is in environmental toxicants as they impact metabolism and immune responses. Laskin has been a long time visitor to the MBL and worked with BRC on the first application of a nitric oxide sensor to single cell studies. 2005 was the first year of this module's activity, which was focused only in the summer months. A group of active investigators from Woods Hole and New Jersey collaborated together between June and September. The group organized a 'Toxicology Roundtable" at the BRC which met weekly during the months of July and August to discuss issues in environmental toxicology and applications of BRC technology in toxicology. Examples of topics included discussion by Hans Laufer on the role of endocrine disruptors in modifying oxidative stress in epithelial cells and