RES FACIL CONSTRUCTION: BREAST CANCER

RES 设施建设：乳腺癌

• 批准号: 6794453
• 负责人: DAVID COWBURN
• 金额: $ 66.67万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794453
• 关键词: biomedical facility; breast neoplasms; building /facility design /renovation; cryoelectron microscopy; protein structure

DESCRIPTION (provided by applicant): The NYSBC, a consortium of nine academic medical research institutions, proposes to construct a 10,000 sq. ft. addition to its existing facilities to house three state-of-the-art cryo EM. The objective is to expand the NYSBC's scientific scope, which currently focuses on magnetic resonance spectroscopy, by creating a resource and program in the complementary field of cryo EM. These new resources will serve a large, internationally-recognized community of National Institutes of Health (NIH)-funded biologists who do not currently have adequate (or any) institutional access to cryo EM. The proposed expansion will serve more than 25 research groups that use cryo EM directly, or in conjunction with crystallography and magnetic resonance spectroscopy, to study proteins and supramolecular machines. Another 40 researchers who do not currently use cryo EM, will be able to undertake more difficult problems in their fields with access to the integrated resources provided by the expanded NYSBC. The NYSBC is located on the campus of City College of New York (CCNY) at 133rd Street and Convent Avenue in Upper Manhattan. It is being constructed in three phases: 1) Phases I and II will house a group of high-field magnetic resonance spectrometers (750, 800 and 900 at MHz); Phase I will be operational by March 31, 2002; and Phase II will be operational by December 31, 2002. This application is for Phase III funding only. It comprises 10,000 sq. ft. to house three cryo EM at 120 kV, 200 kV, and 300 kV, and necessary ancillary activities.

描述（由申请人提供）：NYSBC 是一个由九家学术医学研究机构组成的联盟，提议在其现有设施的基础上再建造一个 10,000 平方英尺的设施，以容纳三台最先进的冷冻电镜。其目标是通过在冷冻电镜互补领域创建资源和计划，扩大 NYSBC 目前专注于磁共振波谱学的科学范围。这些新资源将为美国国立卫生研究院 (NIH) 资助的大型、国际公认的生物学家社区提供服务，这些生物学家目前没有足够的（或任何）机构机会获得冷冻电镜。拟议的扩展将为超过 25 个研究小组提供服务，这些研究小组直接使用冷冻电镜或与晶体学和磁共振波谱相结合来研究蛋白质和超分子机器。另外 40 名目前不使用冷冻电镜的研究人员将能够利用扩大后的 NYSBC 提供的综合资源来解决其领域内更困难的问题。 NYSBC 位于纽约城市学院 (CCNY) 校园内，位于曼哈顿上城 133 街和修道院大道交汇处。它分三个阶段建设：1）一期和二期将安装一组高场磁共振波谱仪（750、800和900兆赫兹）；第一期将于2002年3月31日投入运行；第二阶段将于 2002 年 12 月 31 日投入运行。本申请仅适用于第三阶段的资金。它占地 10,000 平方英尺，可容纳三个 120 kV、200 kV 和 300 kV 的冷冻电镜以及必要的辅助活动。