RES FACIL CONSTRUCTION: GENOMICS, PROTEIN

描述(申请人提供)：NYSBC是由9个学术医学研究机构组成的联合体，拟建设1万平方米。英国《金融时报》除了现有的设施外，还将容纳三个最先进的低温EM。其目标是通过创建低温EM互补领域的资源和计划，扩大NYSBC目前专注于磁共振光谱学的科学范围。这些新资源将为国家卫生研究院(NIH)资助的生物学家组成的国际公认的大型社区提供服务，这些生物学家目前没有足够的(或任何)机构渠道获得低温EM。拟议中的扩展将服务于25个以上的研究小组，这些研究小组直接使用低温EM，或与结晶学和磁共振光谱学结合使用，以研究蛋白质和超分子机器。另外40名目前没有使用低温EM的研究人员将能够利用扩大后的NYSBC提供的综合资源，在他们的领域从事更困难的问题。NYSBC位于曼哈顿上城133街和修道院大道交汇处的纽约城市学院(CCNY)校园内。它正分三个阶段建造：1)第一阶段和第二阶段将容纳一组高场磁共振光谱仪(750、800和900兆赫)；第一阶段将于2002年3月31日投入使用；第二阶段将于2002年12月31日投入使用。本申请只适用于第三阶段的资助。它有10,000平方米。英国《金融时报》容纳120千伏、200千伏和300千伏三个低温EM以及必要的辅助活动。

DESCRIPTION (provided by applicant): The NYSBC, a consortium of nine academic medical research institutions, proposes to construct a 10,000 sq. ft. addition to its existing facilities to house three state-of-the-art cryo EM. The objective is to expand the NYSBC's scientific scope, which currently focuses on magnetic resonance spectroscopy, by creating a resource and program in the complementary field of cryo EM. These new resources will serve a large, internationally-recognized community of National Institutes of Health (NIH)-funded biologists who do not currently have adequate (or any) institutional access to cryo EM. The proposed expansion will serve more than 25 research groups that use cryo EM directly, or in conjunction with crystallography and magnetic resonance spectroscopy, to study proteins and supramolecular machines. Another 40 researchers who do not currently use cryo EM, will be able to undertake more difficult problems in their fields with access to the integrated resources provided by the expanded NYSBC. The NYSBC is located on the campus of City College of New York (CCNY) at 133rd Street and Convent Avenue in Upper Manhattan. It is being constructed in three phases: 1) Phases I and II will house a group of high-field magnetic resonance spectrometers (750, 800 and 900 at MHz); Phase I will be operational by March 31, 2002; and Phase II will be operational by December 31, 2002. This application is for Phase III funding only. It comprises 10,000 sq. ft. to house three cryo EM at 120 kV, 200 kV, and 300 kV, and necessary ancillary activities.