900 MHz NMR Spectrometer for Structural Biology

产品说明：纽约结构生物学中心是一家501（c）（3）公司，由代表九个研究机构的董事会管理，提议购买一台900 MHz NMR光谱仪用于结构生物学研究，并寻求光谱仪成本的艺术液体。主要调查员和其他调查员将共同使用这一资源，并鼓励其他用户。 要建立的研究包括蛋白质和核酸的结构测定，动力学研究，蛋白质折叠，同位素标记方法的发展，应用于更高的分子量，并应用于膜蛋白。这些研究是旨在了解结构生物学中的基本科学问题以及参与许多发育疾病，癌症，肌肉骨骼疾病，神经疾病和传染病的生理和病理过程的计划的一部分。 研究人员包括使用NMR的领先结构生物学家，以及该地区领先的实验学家和方法开发人员。这种丰富的智力环境将是富有成效的科学生产力，创造力和协作使用拟议的工具。 900 MHz光谱仪将安装在一个10，000平方英尺的如果.扩建部分正在建设中，与NYSBC现有的实验室相邻。研究人员将有机会使用800 MHz和更低场的仪器，以便900 MHz系统可以有选择地用于那些需要超高场的实验工作者。 超高场的具体要求S包括使用横向优化弛豫光谱（TROSY）及其衍生物、用于测量残余偶极耦合的磁取向和场依赖性CSA、动力学和其他弛豫相关现象的大分子量系统的应用。

DESCRIPTION: The New York Structural Biology Center, a 501(c) (3) corporation governed by a Board representing nine research institutions, proposes to purchase a 900 MHz NMR spectrometer for research in structural biology, and seeks fluids for art of the Cost of the spectrometer. The principal investigators and other investigators will share in the use of this resource, and will encourage other users. Research to be constructed includes structure determination of proteins and nucleic acids, dynamics studies, protein folding, and development of methods of isotopic labeling, application to higher molecular weights, and application to membrane proteins. These studies are part of programs aimed at understanding both basic scientific problems in structural biology and at physiological and pathological processes involved in many diseases of development, cancer, muscle skeletal disorders, neurological diseases, and infectious diseases. The investigators include leading structural biologists using NMR, and leading experimentalists and methods developers in the area. This rich intellectual environment will be fruitful for scientific productivity, creativity, and collaboration using the proposed instrument. The 900 MHz spectrometer will be housed in a 10,000 sq. if. extension now in construction, contiguous with the NYSBC's existing laboratory. The investigators will have access to' 800 MHz and lower field instruments, so that the 900 MHz system Can be used selectively for those experimentalists requiring ultra high field. Specific requirement S for ultra high field include applications to large molecular weight systems using transverse optimize relaxation spectroscopy (TROSY) and its ''derivatives, magnetic orientation for measurement of residual dipolar couplings, and field-dependent CSA, dynamics, and other relaxation-related phenomena.