EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTS: CHIMPANZEE

描述(由申请者提供)：具体目标1是设计和建造更多的黑猩猩设施，这些设施将为另外40到60只动物提供住所，并补充国家研究资源中心(NCRR)最近授予的黑猩猩生物医学研究补助金(CBRG)中目前处于设计开发阶段的设施建设(100只动物)。受感染的黑猩猩的住房、管理和保健需要专门的知识和经验，以满足它们的身体、心理和社会需求。这些设施旨在允许黑猩猩进行生物医学研究，并为长期感染对人类构成风险的可传播病原体的黑猩猩提供高质量的长期住所。这将为未来20年的国家卫生研究重点和丰富的环境中的黑猩猩种群提供稀缺资源，使具有类似实验历史的动物能够得到社会群体的收容。在具体目标2中，DVS将提供一个在高质量黑猩猩研究、护理和福利方面享誉全国的创新项目。生物医学研究基础设施和经验已经到位，可以支持使用黑猩猩模型的研究人员提供复杂的现场或非现场研究支持。这些设施将使研究人员能够继续按照美国农业部、公共卫生服务部和认证管理部门的所有现行标准来维护美国国立卫生研究院(NIH)的黑猩猩，事实上，将更密切地满足公众对在丰富的环境中维护黑猩猩的期望。在具体目标3中，这些拟议设施将有助于满足NIH和NCRR比较医学主任以及NCRR黑猩猩管理计划(CHINP)项目主任所表达的对长期黑猩猩生物医学研究设施的关键计划需求。

DESCRIPTION (provided by applicant): Specific Aim 1 is to design and construct additional chimpanzee facilities that will provide housing for 40 to 60 additional animals and complement the facility construction currently in the design development phase (for 100 animals) in the recently-awarded Chimpanzee Biomedical Research Grant (CBRG) from the National Center for Research Resources (NCRR). The housing, management and health care of infected chimpanzees require specialized knowledge and experience to provide for their physical, psychological and social needs. The facilities are designed to allow for chimpanzee biomedical research and provide high quality, long-term housing of chimpanzees chronically infected with transmissible agents that pose a risk to humans. This will provide a scarce resource for national health research priorities over the next twenty years and the chimpanzee populations in an enriched environment that allows social group housing of animals with similar experimental histories. In Specific Aim 2, the DVS will provide an innovative program that has a national reputation for high quality chimpanzee research, care and welfare. The biomedical research infrastructure and experience is already in place to support sophisticated on-site or off-site research support for investigators using the chimpanzee model. These facilities will allow the investigators to continue to maintain National Institutes of Health (NIH) chimpanzees in compliance with all current United States Department of Agriculture, Public Health Service, and accreditation regulatory standards and, in fact, will more closely meet the public's expectations for maintaining chimpanzees in an enriched environment. In Specific Aim 3, these proposed facilities will assist in meeting the expressed critical program needs for long-term chimpanzee biomedical research facilities as expressed by both the NIH and NCRR Director of Comparative Medicine and the Program Director for the NCRR Chimpanzee Management Plan (ChiMP).