ANIMAL BREEDING AND RESEARCH PROGRAM

我们提出了一个大规模的衍生策略的延续， 建立恒河猴SPF生产程序。 1988年， 身体、行为和生殖健康的传统恒河猴 猴子们致力于建立一个没有 逆转录病毒和疱疹B病毒（SPF）。最初提出的推导 战略超出了第一个授予期的预期 100%。加强病毒筛查、分离和管理， 不同定义的动物种群导致了408只动物， 1岁和5岁，符合SPF定义。疱疹B病毒 该人群的发病率为零;从未出现过SRV阳性 群体中的动物和所有SRV不确定性已被删除， 所有STLV和SIV阳性或不确定动物。该人群 代表了我们真正的SPF生产群体的核心。 过去五年的育种统计数据令人印象深刻， 考虑到进行密集的病毒筛查的破坏性， 实验室出生的婴儿通过顺序的单，双，和同行住房。的 我们的大规模衍生战略的成功， 为改进延续战略和加强 保证我们能够建立一个受到良好保护的封闭生产 无特定病原体的菌落。专业技术 迄今已成功策划方案的团队将继续 实施更加创新和改进的方案。 虽然建立了SPF生产群，并实现了财务 独立性将是我们的主要目标，受赠机构（大学） （德克萨斯州）再次提出一个方案联盟， 相关调查，并最大限度地利用这种独特的动物 人口联合会的目标与加强 SPF生产的长期成本效益和质量改进 程序.行为伴侣研究基金（布卢姆史密斯）地址 应用行为原则来提高行为能力， 幸福的衍生生产殖民地和未来的生产 行为正常的研究动物和替代育种者。我们 建议动物资源支持的一个社区处理 遗传学

We propose the continuation of a large-scale derivation strategy to establish a rhesus monkey SPF production program. In 1988, 286 physically, behaviorally, and reproductively healthy conventional rhesus monkeys were dedicated to establishing a rhesus breeding colony free of retroviruses and Herpes B virus (SPF). The initially proposed derivation strategy has exceeded the projected expectations of the first award period by 100%. The intensive viral screening, separation and management of six differently defined animal populations has resulted in 408 animals between one and five years of age that meet the SPF definition. Herpes B virus incidence in this population is zero; there has never been an SRV positive animal in the population and all SRV indeterminates have been removed as have all STLV and SIV positive or indeterminate animals. This population represents the nucleus of our true SPF production colony. Breeding statistics during the past five years have been impressive, considering the disruptive nature of doing intensive viral screening of lab-born infants through sequential single-, pair-, and peer-housing. The success of our large scale derivation strategy has provided vital information for improving the continuation strategy and strengthening assurances that we can establish a well-protected, closed production colony free of the specified pathogens. The professional and technical team that has orchestrated programmatic success to date will continue to implement an even more innovative and improved program. Although establishing the SPF production colony and achieving financial independence will be our primary goal, the grantee institution (University of Texas) is again proposing a programmatic consortium to perform resource relevant investigations and maximize the use of this unique animal population. The consortium goals have direct relevance to enhancing the long-term cost-effectiveness and quality improvement of the SPF production program. The behavioral companion research grant (Bloomsmith) addresses applied behavioral principles to enhance the behavioral competence and well-being of the derived production colony and the future production of behaviorally normal investigative animals and replacement breeders. We are proposing the animal resource support of a subcontract dealing with genetics.