SPF ANIMAL BREEDING AND RESEARCH PROGRAM

描述（改编自申请人摘要）：申请人提出 继续大规模的、财政独立的生产资源 SPF恒河猴的样本，可以用于艾滋病相关的研究。 1988年， 286只健康恒河猴进行衍生 设计用于建立SPF菌落的策略。 截至1995年12月31日， 这个群体已经进化成533只健康的、多产的、社会性丰富的恒河猴 猴子致力于满足远程，国家研究和测试 需求 申请人目前的SPF成就包括九年的 持续的病毒筛查和剔除阳性和不确定检测 动物 大部分殖民地也符合长距离SPF 所有育种者都有SPF父母的标准（目前为73%）， 与病毒阳性伴侣一起居住的时间史（目前 58%）。 申请人的设施和管理策略保证封闭 在符合以下条件的环境中，SPF恒河猴的群体保护 当前社会对动物福利的期望。 育种统计 在过去的八年里，SPF动物的销售情况在 应用程序. 申请人预计能够生产大约 每年100-200只SPF恒河猴，用于下一阶段的研究 奖励期。 在下一个奖励期间，研究人员可以选择SPF 猕猴通过亲缘系数增加免疫同质性， 并且也可以具有先前建立的单个细胞系伴随 那个禽兽 遗传学和行为免疫学伴侣 研究拨款与SPF恒河猴质量保证直接相关， 蜂群管理、生产力和福祉。 在殖民地中繁殖 不需要中断资源来支持调查人员， 遗传学、行为学和免疫学领域。

DESCRIPTION (Adapted from the applicant's abstract): The applicants propose continuation of a large-scale, financially independent production resource of SPF rhesus monkeys that can be used in AIDS-related research. In 1988, 286 healthy conventional rhesus monkeys were dedicated to a derivation strategy designed to establish the SPF colony. As of December 31, 1995, this colony has evolved to 533 healthy, productive, socially-enriched rhesus monkeys dedicated to meeting long range, national research and testing needs. The applicant's current SPF achievements include nine years of sustained viral screening and culling of positive and indeterminate test animals. A significant portion of the colony also meets the long range SPF criteria of all breeders having SPF parents (currently 73%), and no life time history of being housed with a virus positive companion (currently 58%). The applicant's facilities and management strategies assure closed colony protection for SPF rhesus monkeys in an environment that meets current societal expectations for animal welfare. Breeding statistics for the past eight years and sales of SPF animals are discussed in the application. The applicants project being able to produce approximately 100-200 SPF rhesus monkeys per year for investigative use during the next award period. During the next award period, investigators can select SPF rhesus monkeys by kinship coefficient to increase immunological homogeneity, and can also have a previously established individual cell line accompany the animal. The genetic subcontract and behavioral immunology companion research grant have direct relevance to SPF rhesus monkey quality assurance, colony management, productivity, and well-being. Breeding in the colony does not have to be disrupted for the resource to support investigators in the fields of genetics, behavior, and immunology.