ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY

（摘自申请人摘要）：本合作协议 结合了两个以前资助的非常成功的项目的优势， 用于黑猩猩的饲养和研究;安德森癌症中心 （UT-MDACC）、巴斯特罗普兽医科学系（DVSB）和 梅萨。 通过与PFA和增加新的住房进行合作， 在DVSB的设施，调查人员可以显着增加的数量， 黑猩猩在一个经验丰富，协调兽医护理，管理， 研究计划。 他们与PFA有详细的谅解备忘录 作为分包商为他们工作 通过将PFA纳入 DVSB以研究为导向的使命，他们可以显着增加 满足建立一个稳定的长期国家的拟议需要的可能性 黑猩猩的生物医学研究资源。 这项申请将致力于186个人口最平衡， 身体和行为健康的黑猩猩 管理一个国际公认的研究机构。 这 专门的殖民地将作为核心资源，以支持同行评审 需要黑猩猩模型的研究。 酌情为 调查人员将因使用这些黑猩猩而受到指控。 除了 对所有年龄的黑猩猩都有生物危害和传统的关押设施， DVSB可以提供分子、病毒、免疫学、解剖学 和临床病理学研究服务。 提高研究者的认识 黑猩猩的可用性，适当的调查住房， DVSB先进的研究支持能力应能增强谨慎的 黑猩猩的研究用途 研究人员提出了新的生物医学研究和住房设施， 可以再养活100到175只黑猩猩 所提出的设计最大限度地 灵活性和选择住房的个人和小型或大型团体。 现有设施和新设施将在浓缩和浓缩之间实现平衡。 保护栖息地。 为了补充设施，他们有足够的 一批敬业、经验丰富的专业技术人员。 他们的所有目标都可以通过满足社会需求的方式实现。 对黑猩猩的人道关怀和使用的期望。 他们将继续进行临床研究，以改善黑猩猩 健康、遗传学、管理和福祉。 正强化训练 技术将得到改进，以增加黑猩猩的自愿合作 进行了大量的研究和调查 拟议计划和 设施有20年的跟踪记录，以证实他们在成本方面的成功， 有效地提供高质量的饲养，护理和研究， 黑猩猩

(Adapted from the applicant's abstract): This cooperative agreement combines the strengths of two previously funded, highly successful programs for chimpanzee care breeding, and research; The UT M.D. Anderson Cancer Center (UT-MDACC), Department of Veterinary Sciences in Bastrop (DVSB) and the PFA in Mesa. Through a subcontract with PFA and the addition of new housing facilities at DVSB, the investigators can significantly increase the number of chimpanzees under an experienced, coordinated veterinary care, management, and research program. They have a detailed Memorandum of Understanding with PFA to perform for them as a subcontractor. By incorporating PFA into the research-oriented mission of DVSB, they can significantly increase the likelihood of satisfying the proposed need for a stable long-term national resource of chimpanzees for biomedical research. This application will dedicate 186 of the most demographically balanced, physically and behaviorally healthy chimpanzees in the country to the management of an internationally recognized research institution. This dedicated colony will serve as a Core resource to support peer-reviewed investigations requiring the chimpanzee model. When appropriate, the investigators will be charged for using these chimpanzees. In addition to having biohazard and conventional holding facilities for all age chimpanzees, the DVSB can provide an array of molecular, viral, immunological, anatomical and clinical pathology research services. Increasing investigator awareness of the availability of chimpanzees, appropriate investigative housing and sophisticated research support capabilities of DVSB should enhance the prudent investigative use of the chimpanzee. The investigators proposed new biomedical research and housing facilities that will support an additional 100-175 chimpanzees. The proposed design maximizes flexibility and options for housing individuals and small or large groups. The current and new facilities will provide a balance between an enriched and a protected habitat. To complement the facilities, they have sufficient numbers of dedicated and experienced professional and technical personnel. All of their objectives can be accomplished in a manner meeting societal expectations for the humane care and use of chimpanzees. They will continue to perform clinical investigations to improve chimpanzee health, genetics, management and well-being. Positive reinforcement training techniques will be refined to increase voluntary cooperation of chimpanzees with numerous research and investigative procedures. The proposed plan and facilities have a 20-year track record to substantiate their success in cost- effective delivery of high quality husbandry, care, and research with the chimpanzee.