DEVELOPMENT AND MAINTENANCE OF BINOCULAR VISION

描述：先天性和婴儿期双眼不平衡影响 3-4%的美国婴儿视力成熟。 这些条件具有 可能导致弱视和双眼视觉异常。 即使在成功恢复透明媒体的治疗后， 对准，和正常的敏锐度，不到1%的患者达到正常 立体视觉 在上一个赠款期间， 婴儿内斜视和先天性单侧白内障显示， 显著改善了立体视觉和对准。 拟议的研究将 在这些调查结果的基础上，评估是否有进一步的改善， 当手术对准完成时， 立体视关键期的开始，是否有严重的损害 立体视觉的影响更强烈的发病错位或 失准的持续时间，更好的立体视锐度结果是否 与更好的长期对齐相关， 剥夺性弱视的遮盖疗法改善了立体视觉结果。 PI最近的工作与鼻颞不对称的视觉诱发电位运动 反应表明，抑制比立体视觉更密切的联系。 提出 研究将在婴儿和患有婴儿型糖尿病的儿童中评估这一假设。 或迟发性内斜视或非共同性斜视。 为了确定 这些感觉异常是否共同发展，VEP运动不对称， 抑制和立体视觉也将在一组婴儿中进行评估， 斜视风险很高。 PI还将探索垂直运动是否 不对称性与垂直分离共同发展或预测垂直分离 偏差 使用新开发的超敏方案，她将评估 弱视婴儿位置性视敏度缺陷的发展，检查 它们与分辨率缺陷的关系，并确定是否 位置敏锐度提供了一种有用的方法来监测/预测成功 闭塞疗法。 在过去的一段时间里，她开发了三个 双眼感觉和运动功能测试，婴儿随机点 立体卡，学前Randot立体视敏度测试，以及视频 Hirschberg系统 在即将到来的赠款期间，她将评估 这些测试的准确性，可靠性和有效性。 视频Hirschberg 系统还将用于研究眼睛对准的共同发展， 正常婴儿的立体视和异常固视的发展 儿科患者的模式。 在基础科学方面，这些研究 将有助于确定必要和充分的条件， 立体视觉的发展。 在临床方面，更好的立体视觉 结果应该提供更稳定的眼睛对准和更好的质量， 生活

DESCRIPTION: Congenital and infantile onset binocular imbalance affect the visual maturation of 3-4% of U.S. infants. These conditions have the potential to cause both amblyopia and abnormalities in binocular vision. Even after treatment which is successful in restoring clear media, good alignment, and normal acuity, less than 1% of patients achieve normal stereoacuity. During the previous grant period, early treatment for infantile esotropia and congenital unilateral cataract were shown to significantly improve stereoacuity and alignment. Proposed studies will build on these findings by evaluating whether further improvements in stereoacuity can be achieved when surgical alignment is accomplished at the onset of the critical period for stereopsis, whether severity of impairment of stereopsis is influenced more strongly by onset of misalignment or by duration of misalignment, weather better stereoacuity outcomes are associated with better long term alignment, and whether progressive occlusion therapy for deprivation amblyopia improves stereoacuity outcomes. The PI recent work with nasal-temporal asymmetries in the VEP motion response suggest a closer link to suppression than to stereopsis. Proposed studies will evaluate this hypothesis in infants and children with infantile or late onset esotropia or incomitant strabismus. In order to determine whether these sensory anomalies co-develop, VEP motion asymmetry, suppression, and stereopsis will also be evaluated in a group of infants at high risk for strabismus. The PI will also explore whether vertical motion asymmetries co-develop with or are predictive of dissociated vertical deviations. Using a newly developed hyperacuity protocol, she will evaluate the development of positional acuity deficits in amblyopic infants, examine their relationship with resolution deficits, and determine whether positional acuity provides a useful approach to monitor/predict the success of occlusion therapy. During the past grant period, she developed three tests of binocular sensory and motor function, the Infant Random Dot Stereocards, the Preschool Randot Stereoacuity test, and the video Hirschberg system. In the upcoming grant period, she will evaluate the accuracy, reliability, and validity of these tests. The video Hirschberg system will also be used to study the co-development of eye alignment and stereopsis in normal infants and the development of abnormal fixation patterns in pediatric patients. On the basic science side, these studies will help to define the necessary and sufficient conditions for the development of stereopsis. On the clinical side, better stereoacuity outcomes should provide more stable eye alignment and better quality of life.