EFFECTS OF TAR IN HUMANS

假设：香烟的“焦油”是生理变化的主要促进剂，这些变化是吸烟相关疾病的标志。理由：烟草加热香烟不会燃烧香烟中含有的烟草，因此减少了> 90%的“焦油”吸入。吸烟者谁改变烟草加热香烟可能开始显示出有利的变化，在人类疾病的生物标志物。方法学：25名吸烟者接受了一系列广泛的测试，包括心肺生理学、胆固醇、外周血白细胞和支气管肺泡灌洗。完成基线研究后，当受试者仍在吸烟时，受试者开始吸烟。在受试者吸烟草加热香烟1个月、6个月和12个月后进行重复测试。10名非吸烟对照受试者将接受一组测试。非配对统计比较用于确定非吸烟者和吸烟者之间的差异，而配对比较用于比较吸烟者从基线值的连续变化。

Hypothesis: Cigarette 'tar' is the major promoter of physiologic changes which are hallmarks of smoking-associated diseases. Rationale: Tobacco-heating cigarettes do not bum the tobacco contained within the cigarette and as a result reduce 'tar' inhalation by > 90%. Smokers who change to tobacco-heating cigarettes may begin to show favorable changes in the biomarkers of human disease. Methodology: Twenty-five smokers undergo a broad series of tests including heart and lung physiology, cholesterol, peripheral leukocytes and bronchoalveolar lavage. After completion of baseline studies while subjects are still smoking tobacco-burning cigarettes, subjects begin smoking tobacco-heating cigarettes. Repeat sets of tests are performed after subjects have smoked tobacco-heating cigarettes for 1 month, 6 months and 12 months. Ten non-smoking control subjects will undergo a single set of tests. Unpaired statistical comparisons are used to establish the differences in non-aasmokers and smokers while paired comparisons are used to compare serial changes in smokers from their baseline values.