INSULIN, INSULIN RESISTANCE, HYPERGLYCEMIA & CARDIOVASCULAR DISEASE

胰岛素、胰岛素抵抗、高血糖

• 批准号: 6308698
• 负责人: STEVEN M. HAFFNER
• 金额: $ 1.64万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308698
• 关键词: blood glucose; cardiovascular disorder; cardiovascular disorder epidemiology; clinical research; disease /disorder proneness /risk; human subject; hyperglycemia; insulin sensitivity /resistance; low density lipoprotein; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference

Non-insulin dependent diabetes (NIDDM) is associated with increased risk for coronary artery, peripheral vascular, and cerebrovascular diseases. It has been hypothesized that cardiovascular disease (CVD) is not a consequence of NIDDM but that both conditions share common antecedents. Risk factors such as obesity, high fasting plasma glucose and total and low-density lipoprotein cholesterol concentrations with low levels of high-density lipoprotein cholesterol, high blood pressure -- all cluster in normoglycemic subjects who subsequently develop impaired glucose tolerance. This study proposes to determine if insulin resistance is associated with increased prevalence of CVD independent of obesity, glycemia, and insulinemia, to determine the impact of insulin resistance on CVD risk factors, to determine if there are ethnic differences in the relationship between insulin resistance and the prevalence of CVD, and to establish the basis for a prospective study to determine if insulin resistance predicts the development of CVD and its risk factors.

非胰岛素依赖型糖尿病(NIDDM)与风险增加相关 用于冠状动脉、外周血管和脑血管疾病。它 已经假设心血管疾病(CVD)不是 NIDDM的后果，但这两种情况是共同的 前因后果。肥胖、空腹血糖过高和 低水平的总和低密度脂蛋白胆固醇浓度 高密度脂蛋白胆固醇、高血压--都聚集在 血糖正常的受试者，随后出现血糖受损 宽容。这项研究建议确定胰岛素抵抗是否是 与独立于肥胖的心血管疾病患病率的增加有关， 血糖和胰岛素血症，以确定胰岛素抵抗对 心血管疾病危险因素，以确定是否存在种族差异 胰岛素抵抗与心血管疾病患病率的关系 为确定胰岛素抵抗是否存在前瞻性研究奠定基础 预测心脑血管疾病的发展及其危险因素。