Molecular Epidemiology of Myelodysplastic Syndromes

骨髓增生异常综合征的分子流行病学

• 批准号: 6335319
• 负责人: Sara S. Strom
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6335319
• 关键词: alcoholism /alcohol abuse; clinical research; cytochrome P450; diet; dyes; dyserythropoietic anemia; gene environment interaction; genetic markers; genetic susceptibility; glutathione transferase; human subject; neoplasm /cancer epidemiology; petroleum oil; radiobiology; smoking; tobacco abuse

Although many reports have been published on the etiology of different types of leukemia, little is known about the risk factors associated with the myelodysplastic syndromes (MDS). Even less is known about the role that genetic susceptibility plays in the development of these syndromes. We propose to conduct a pilot case-control study of 180 MDS patients registered at the U. of Texas M. D. Anderson Cancer Center (MDACC) and 180 controls selected from friends and spouses who accompany patients to different MDACC clinics. Controls will be matched to the cases on age, sex, ethnicity, and state of residence. We propose to accrue 130 new cases and 130 controls to add to the 100 participants (50 cases and 50 controls) already collected. Epidemiological and demographic information obtained by personal interviews will be integrated with clinical, including cytogenetics, and genotypic markers. All participants will be genotyped for the following markers associated with activation and detoxification of chemical carcinogens (CYP2E1, CYP1A1, CYP1B1, GSTT1, GSTM1, GSTP1, NQO1, and MPO). This pilot study will provide insight in the understanding about the role that these genetic markers, along with epidemiological and clinical risk factors play in the identification of people at risk of MDS development. This study will provide data for a large multicenter study. The identification of risk factors associated with the development of MDS is an important health concern, as it could lead to the eventual prevention of this syndrome and consequent reduction in the incidence of AML.

虽然关于不同类型白血病的病因学已有许多报道，但与骨髓增生异常综合征（MDS）相关的危险因素却知之甚少。关于遗传易感性在这些综合征的发展中所起的作用，我们所知什少。我们建议对180例在美国登记的MDS患者进行一项初步的病例对照研究。德克萨斯M。D.安德森癌症中心（MDACC）和180名对照组，对照组选自陪同患者到不同MDACC诊所的朋友和配偶。对照组将在年龄、性别、种族和居住州方面与病例相匹配。我们建议在已经收集的100例参与者（50例病例和50例对照）的基础上增加130例新病例和130例对照。通过个人访谈获得的流行病学和人口统计学信息将与临床（包括细胞遗传学）和基因型标记物相结合。所有受试者将接受以下与化学致癌物活化和解毒相关的标志物（CYP2E1、CYP1A1、CYP1B1、GSTT1、GSTM1、GSTP1、NQO1和MPO）的基因分型。这项初步研究将提供深入了解的作用，这些遗传标记物，沿着流行病学和临床风险因素在识别的人在MDS发展的风险。本研究将为一项大型多中心研究提供数据。识别与MDS发展相关的风险因素是一个重要的健康问题，因为它可能导致最终预防这种综合征，从而降低AML的发病率。