PROSTATE CANCER IN MEXICANS AMERICANS & AFRICAN AMERICAN

墨西哥裔美国人的前列腺癌

• 批准号: 6377759
• 负责人: Sara S. Strom
• 金额: $ 46.72万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377759
• 关键词: African American; Mexican Americans; androgen receptor; cancer risk; clinical research; diet; disease /disorder etiology; gene environment interaction; gene interaction; human subject; male; neoplasm /cancer epidemiology; nutrition related tag; prostate neoplasms; racial /ethnic difference; socioeconomics; vitamin D receptors

Prostate cancer is the leading incident cancer and the second leading cause of cancer deaths among men in the three major U.S. ethnic groups. However, those rates differ markedly among these groups. The racial differences in prostate cancer incidence and mortality could provide important clues to the etiology of the disease that could be exploited to further our understanding of prostate carcinogenesis. Prostate cancer is a model site for the study of the interplay of gene-environment interactions. In this proposed study, we will examine environmental factors in concert with genetic susceptibility in two ethnic groups with contrasting prostate cancer rates, African Americans and Mexican Americans, from a well-defined geographic area. We propose a population-based case-control study of genotypic, phenotypic, environmental and sociodemographic contributors to the etiology of prostate cancer in African Americans and Mexican Americans who are residents of the Houston area (Harris County, Texas). We will enroll 550 prostate cancer cases (200 Mexican Americans and 350 African Americans) and 750 controls (400 Mexican Americans and 350 African Americans) matched on age and race/ethnicity. Constitutional markers of genetic susceptibility and hormonal modulation, such as androgen receptor, 5-alpha-reductase type II, CYP17, CYP1B1, 3-beta-hydroxsteroid type II and vitamin D receptor, will be analyzed to determine if genotypic differences are associated with prostate cancer risk. Few studies have focused on minority populations, especially Hispanics, from a defined geographic area. Understanding how genetic predisposition and exogenous exposures interact to determine prostate cancer susceptibility will allow the development of more effective ethnic-specific prevention strategies.

前列腺癌是美国三大族裔男性中最常见的癌症，也是导致癌症死亡的第二大原因。 然而，这些比率在这些群体之间差别很大。 前列腺癌发病率和死亡率的种族差异可以为疾病的病因学提供重要线索，这些线索可以用于进一步了解前列腺癌的发生。 前列腺癌是研究基因-环境相互作用的模型部位。 在这项拟议的研究中，我们将研究环境因素与两个种族群体的遗传易感性，这两个种族群体的前列腺癌发病率不同，非洲裔美国人和墨西哥裔美国人，来自一个明确的地理区域。我们提出了一个以人群为基础的病例对照研究的基因型，表型，环境和社会人口学的贡献者前列腺癌的病因在非裔美国人和墨西哥裔美国人谁是休斯顿地区（哈里斯县，得克萨斯州）的居民。 我们将入组550例前列腺癌病例（200例墨西哥裔美国人和350例非洲裔美国人）和750例对照（400例墨西哥裔美国人和350例非洲裔美国人），这些病例在年龄和人种/种族上匹配。 将分析遗传易感性和激素调节的体质标志物，如雄激素受体、5-α-还原酶II型、CYP 17、CYP 1B 1、3-β-羟类固醇II型和维生素D受体，以确定基因型差异是否与前列腺癌风险相关。很少有研究集中在少数民族人口，特别是西班牙裔，从一个确定的地理区域。 了解遗传易感性和外源性暴露如何相互作用以确定前列腺癌的易感性，将有助于制定更有效的种族特异性预防策略。