A MODEL FOR OCCUPATIONAL EPICONDYLITIS

职业性上髁炎模型

• 批准号: 6446084
• 负责人: KAREN B KING
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446084
• 关键词: disease /disorder model; elbow; histology; laboratory rabbit; model design /development; occupational disease /disorder; repetitive motion injury

My doctoral and postdoctoral training has focused on identifying- and measuring proteins associated with degenerative changes in cartilage and tendon due to loading. My short-term goals are to use my strengths in cell and molecular biology in a research setting where structural tissue loading can be quantified to investigate the dose-response relationships of various measures of load to connective tissue disease (e.g., osteoarthritis, tendonitis). My long-term goals are to establish a solid academic research foundation in the biology of connective tissue diseases associated with work. The Division of Occupational and Environmental Medicine at UCSF, its Ergonomics Program, the Orthopaedic Research Laboratory, and the new Center for Tissue Engineering provide an ideal setting to achieve these goals. I have accepted a junior faculty position with potential for advancement. Eighty percent of my time is protected to carry out the research identified in this award. Ample laboratory space and all major equipment needs are provided in the new Center for Tissue Engineering and office space is provided at the Ergonomics Laboratory. Associate Professors Rempel and Lotz will provide mentorship with monthly meetings to guide my academic progress. Advanced training in occupational biomechanics is supported. The research plan involves modifying a repetitive finger loading rabbit model to investigate epicondylitis. The specific aims are: (1) develop and validate the model, (2) identify relationships between the severity and location of the biochemical and histologic outcome measures, and (3) determine exposure-response relationships of force and repetition on the biologically important histologic and biochemical outcome measures. The results will provide a foundation to examine the relative importance of force, repetition, recovery, and duration in the pathogenesis of work-related epicondylitis.

我的博士和博士后培训主要集中在识别和测量与软骨和肌腱因负荷而发生退行性变化相关的蛋白质。 我的短期目标是利用我在细胞和分子生物学方面的优势，在研究环境中，可以量化结构组织负荷，以研究各种负荷措施与结缔组织疾病的剂量反应关系（例如，骨关节炎、肌腱炎）。 我的长期目标是在与工作相关的结缔组织疾病生物学方面建立坚实的学术研究基础。加州大学旧金山分校的职业和环境医学部，其人体工程学项目，矫形研究实验室和新的组织工程中心为实现这些目标提供了理想的环境。 我已经接受了一个有晋升潜力的初级教师职位。 我80%的时间被保护来进行这个奖项中确定的研究。充足的实验室空间和所有主要设备的需求提供了新的中心组织工程和办公空间提供了人体工程学实验室。 副教授Rempel和Lotz将提供每月会议指导我的学术进步。 支持职业生物力学的高级培训。研究计划包括修改一个重复的手指负荷兔模型，以调查上髁炎。 具体目标是：（1）开发和验证模型，（2）确定生化和组织学结果测量的严重程度和位置之间的关系，以及（3）确定生物学上重要的组织学和生化结果测量上的力和重复的重复性-响应关系。 研究结果将为探讨力量、重复、恢复和持续时间在工作相关性上髁炎发病机制中的相对重要性提供基础。