VIRUSES AND CANCER

定义病毒肿瘤发生的复杂机制需要至少三个研究领域的广泛理解：分子和细胞生物学、免疫学和病毒学。拟议的培训计划的目标是为研究生和博士后提供一个具有挑战性和丰富的科学环境，在这三个广泛但相互关联的领域中可以进行正式和非正式的培训。培训教师的广泛科学兴趣创造了一个混合的研究领域，其中许多包括病毒系统，以解剖正常细胞与癌细胞内发生的分子事件。具体的研究项目包括(a)分子和细胞生物学：细胞生长和基因表达的调控、癌基因、信号转导和肿瘤转化机制；(b)免疫表达、癌基因、信号转导和肿瘤转化机制；(b)免疫学;(c)病毒学-利用腺病毒、巨细胞病毒、乙肝病毒、单纯疱疹病毒、乳头状瘤病毒、乳头状瘤病毒和逆转录病毒进行病毒复制、组装、肿瘤发生、发病机制、潜伏期和基因调控的分子研究。与拟议培训补助金有关的培训人员在微生物学和免疫学系的主要学术任命。然而，每个培训师都与跨部门和学院边界的多个跨学科研究生项目有关。有资格获得培训补助金的研究生可能与以下几个研究生课程中的一个相关，包括化学生物学、细胞和分子生物学、遗传学、微生物学和免疫学、分子医学和神经科学。培训师从各种各样的项目中招收学生的潜力有助于确保有大量高素质的学生可以预约参加培训补助金。研究生和博士后培训计划包括一个充满活力的研究环境，拥有优秀的研究和核心支持设施，以及富有成效和资金充足的研究项目的教师研究实验室。研究和培训环境进一步加强了各种实验室之间的互动，以及期刊俱乐部，学生研讨会和访问科学家研讨会计划。最后，培训计划中强调的研究领域提供了一个广泛的基础，在这个基础上，有创造力的学生和博士后可以在柑橘和癌症领域的研究中建立一个富有成效的职业生涯。

Defining the complex mechanisms of viral oncogenesis requires a broad understanding in at least three areas of research: molecular and cellular biology, immunology, and virology. It is the goal of the proposed training program to provide graduate students and postdoctoral fellows a challenging and enriched scientific environment in which both formal and informal training within these three broad, but interrelated areas can occur. The breadth of the scientific interests of the training faculty create a blend of research areas, many of which incorporate virus systems to dissect the molecular events that occur within the normal versus the cancer cell. The specific research programs include (a) molecular and cellular biology-regulation of cell growth and gene expression, oncogenes, signal transduction, and mechanisms of neoplastic transformation; (b) immunology-expression, oncogenes, signal transduction, and mechanisms of neoplastic transformation; (b) immunology; and (c) virology-molecular studies of virus replication, assembly, oncogenesis, pathogenesis, latency, and gene regulation using adeno, cytomegalo, hepatitis B, herpes simplex, papilloma, papova, and retroviruses. The trainers associated with the proposed training grant have their primary academic appointments within the Department of Microbiology and Immunology. However, each of the trainers is associated with multiple interdisciplinary graduate programs which cross departmental and college boundaries. Graduate students eligible for appointment on the training grant may be associated with one of several graduate programs including Chemical Biology, Cell and Molecular Biology, Genetics, Microbiology and Immunology, Molecular Medicine, and Neurosciences. The potential of the trainers to recruit students from such a variety of programs helps to insure that a significant pool of highly qualified students will be available for appointment to the training grant. The training program for graduate students and postdoctoral fellows includes a dynamic research environment that has excellent research and core support facilities and faculty research laboratories with productive and well funded research programs. The research and training environment is further enhanced by numerous interactions among the various laboratories as well as journal clubs, student seminars, and visiting scientist seminar programs. Finally, the research areas of emphasis within the training program provide a broad foundation on which a creative student and postdoctoral fellow can base a productive career in research in the area of citruses and cancer.