Viruses and Cancer

病毒和癌症

• 批准号: 7646530
• 负责人: Richard Courtney
• 金额: $ 24.32万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-06 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7646530
• 关键词: Malignant Neoplasms; Virus

DESCRIPTION (provided by applicant): Understanding the complex mechanisms of viral oncogenesis requires a broad understanding in at least three areas of research: virology, molecular and cellular biology, and immunology. It is the goal of the proposed training program to provide graduate students and postdoctoral fellows a challenging and supportive scientific environment in which both formal and informal training occurs within these three broad, but interrelated areas. The breadth of the scientific interests of the training faculty create a blend of research areas, many of which incorporate virus systems to dissect the molecular events that occur within the normal vs. the cancer cell. The specific research programs include (a) molecular and cellular biology: regulation of cell growth and gene expression, oncogenes, cell signaling, and mechanisms of neoplastic transformation; (b) immunology: antigen processing, viral and tumor immunology, and the role of endocrine factors on the cellular immune response; and (c) virology: molecular studies of virus replication assembly, oncogenesis, pathogenesis, and gene regulation using virus systems that include adenoviruses, hepatitis viruses, herpes simplex viruses, papillomaviruses, polyomaviruses, and retroviruses. The trainers associated with the proposed training grant have their primary academic appointments within either the Departments of Microbiology and Immunology, Medicine, Pathology, or Pediatrics. Each of the trainers directs productive and well-funded research programs and has a strong commitment towards the training of young scientists. Nearly 50% of the research funding that supports the research programs of the trainers is from the National Cancer Institute of the National Institutes of Health. Each of the trainers is associated with multiple interdisciplinary graduate programs that cross departmental and college boundaries. A major new development at the Penn State College of Medicine is the recent establishment of the Penn State Cancer Institute. The establishment of the Cancer Institute has enhanced the training environment for young scientists interested in cancer. The training program for graduate students and postdoctoral fellows includes a dynamic research environment that has excellent research and core support facilities and well-equipped faculty research laboratories. The research training environment is further enhanced by interactions among the research programs as well as numerous seminars, journal clubs and symposia and special experiences that enhance the cancer training environment. The proposed training program provides a comprehensive training experience for trainees who are interested in a career in the area of virus and cancer research.

描述(由申请人提供)：了解病毒致癌的复杂机制需要至少在三个研究领域有广泛的理解：病毒学、分子和细胞生物学以及免疫学。拟议培训计划的目标是为研究生和博士后研究员提供一个具有挑战性和支持性的科学环境，在这个环境中，正式和非正式培训都在这三个广泛但相互关联的领域进行。培训教师的科学兴趣的广度创造了一个混合的研究领域，其中许多领域结合了病毒系统来剖析发生在正常细胞和癌细胞之间的分子事件。具体研究项目包括(A)分子和细胞生物学：调节细胞生长和基因表达、癌基因、细胞信号和肿瘤转化机制；(B)免疫学：抗原处理、病毒和肿瘤免疫学，以及内分泌因子对细胞免疫反应的作用；(C)病毒学：使用包括腺病毒、肝炎病毒、单纯疱疹病毒、乳头瘤病毒、多瘤病毒和逆转录病毒在内的病毒系统，对病毒复制组装、致癌、发病机制和基因调控进行分子研究。与拟议的培训拨款相关的培训员的主要学术任命是在微生物学和免疫学、内科、病理学或儿科。每一位培训者都指导着富有成效和资金充足的研究项目，并对年轻科学家的培训有着坚定的承诺。支持培训者研究计划的研究资金中，近50%来自美国国立卫生研究院的国家癌症研究所。每个培训师都与多个跨学科的研究生项目相关联，这些项目跨越了院系和学院的界限。宾夕法尼亚州立医学院的一项重大新发展是最近成立了宾夕法尼亚州立癌症研究所。癌症研究所的成立改善了对癌症感兴趣的青年科学家的培训环境。针对研究生和博士后研究员的培训计划包括一个充满活力的研究环境，该环境拥有一流的研究和核心支持设施以及设备齐全的教员研究实验室。研究项目之间的互动以及众多研讨会、期刊俱乐部和研讨会以及改善癌症培训环境的特殊经验进一步加强了研究培训环境。拟议的培训计划为对病毒和癌症研究领域的职业感兴趣的受训者提供了全面的培训体验。