Cancer Neoantigens, Vaccines and Viruses

癌症新抗原、疫苗和病毒

基本信息

批准号：
10233861
负责人：
Thale Cross Jarvis
金额：
$ 0.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10233861
关键词：
Address Antigen Targeting Antitumor Response Area Basic Science Canada Cancer Vaccines Clinic Clinical Clinical Sciences Collaborations Conflict (Psychology)Development Disease Educational workshop Future Immunology Immunotherapeutic agent Immunotherapy Industrialization Knowledge Learning Malignant Neoplasms Methodology Methods Modality Modeling Outcome Research Research Personnel Scientific Advances and Accomplishments Scientist Speed T-Lymphocyte Technology Therapeutic Translations Tumor Antigens Tumor Immunity Vaccines Viral Viral Antigens Viral Cancer Virus Work base cancer immunotherapy clinical implementation clinical practice design insight interest learning network meetings multidisciplinary neoantigen vaccine neoantigens next generation novel novel strategies novel therapeutic intervention posters programs symposium tumor tumor microenvironment vaccine platform

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Cancer Neoantigens, Vaccines and Viruses, organized by Drs. Catherine J. Wu, Robert D. Schreiber and Cornelis J.M. Melief. The conference will be held in Vancouver, BC Canada from June 27- July 1, 2021. Advances in cancer immunotherapy are rapidly transforming the treatment landscape across cancers, but a critical challenge in the field is understanding how we can better drive T cells into tumors, and hence make them available for mounting productive anti-tumor responses. The fields of viral and cancer immunity share many parallels, and insights learned from each area can expand our collective knowledge of how to address this challenge. Cancer vaccines are a valuable immunotherapeutic modality, capable of expanding the repertoire of tumor-specific T cells and have the potential to be productively combined with complementary therapeutic approaches. This conference program was designed to highlight the exciting recent clinical and scientific advances, including the identification of novel antigen targets, new understanding of how the tumor microenvironment is immunoregulated and modulated by cancer immunotherapies, and the development of novel therapeutic approaches. Together, the collective shared knowledge gained from interdisciplinary interactions from this meeting promise to open the path for consideration of novel approaches for the design of more effective cancer immunotherapies.

抽象的请求支持Keystone研讨会会议，标题为癌症新抗原，疫苗和病毒，由Drs组织。 Catherine J. Wu，Robert D. Schreiber和Cornelis J.Me Melief。会议将从2021年6月27日至7月1日在不列颠哥伦比亚省温哥华举行。癌症免疫疗法的进展正在迅速改变癌症的治疗局势，但该领域的关键挑战是了解我们如何更好地将T细胞驱动到肿瘤中，从而使它们可用于安装生产性抗肿瘤反应。病毒和癌症免疫的田地共享许多相似之处，从每个领域学到的见解都可以扩大我们有关如何解决的集体知识这个挑战。癌症疫苗是一种有价值的免疫治疗方式，能够扩展肿瘤特异性T细胞的曲目，并具有与互补的有效结合的潜力治疗方法。该会议计划旨在强调令人兴奋的近期临床和科学进步，包括鉴定新型抗原靶标，对肿瘤的新理解微环境受到癌症免疫疗法的免疫调节和调节，并发展新颖的治疗方法。共同从跨学科获得的集体共享知识这次会议的互动有望为考虑设计的新方法打开道路更有效的癌症免疫疗法。