Career training in bladder control neural protheses

膀胱控制神经假体的职业培训

• 批准号: 6320682
• 负责人: Kenneth J. Gustafson
• 金额: $ 10.39万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6320682
• 关键词: assistive device /technology; bioengineering /biomedical engineering; biomedical equipment development; cats; electronic stimulator; electrophysiology; human subject; medical implant science; nervous system prosthesis; patient oriented research; rehabilitation; spinal cord injury; urinary incontinence; urinary tract prosthesis

DESCRIPTION (Adapted from Application's Description): Dr. Gustafson is an engineer committed to establishing a career in applied neurophysiology research and development of neural prosthetic devices to restore function in individuals with neurological disorders. His short-term career goals are to develop solid foundations in electrophysiological experimental techniques, neural prostheses, genitourinary anatomy and current medical practices. The proposed career development plan will train Dr. Gustafson in 1) electrophysiological experimental techniques and neuroprostheses; 2) genitourinary-related anatomy, physiology and medical practices, and rehabilitative issues for individuals with spinal cord injury (SCI); and 3) independent career development and translational research. Mentors at Case Western Reserve University (CWRU), MetroHealth Medical Center (MHMC) and the Cleveland Functional Electrical Stimulation Center (FESC) will provide training and expertise, and monitor and support Dr. Gustafson's career advancement. The existing collaborative nature of this research and training environment is suited to the multi-disciplinary nature of the project and Dr. Gustafson's career goals in biomedical research. In addition to didactic instruction and structured clinical training, parallel research projects in both animals and humans with SCI are integrated into the career development plan. The research plan will investigate the underlying neurophysiology involved in control of continence and micturition using selective electrical recording and stimulation of individual nerve fascicles of the pudendal nerve. First, the individual pudendal nerve branches that allow the greatest efficacy to sense the onset of reflex bladder contractions, abolish reflex bladder contractions and elicit coordinated micturition will be identified. Second, selective control of these 3 functions with a single nerve cuff placed on the pudendal nerve will be examined. Anatomical cadaver studies and finite element modeling will be combined to evaluate and improve device selectivity. Loss of bladder control is a significant problem in individuals with neurological disorders and SCI; development of an effective, peripherally located neuroprosthesis would significantly improve clinical options for these individuals. This career development plan will establish Dr. Gustafson as an independent investigator in biomedical research and prepare him to lead research efforts in the development of neural prostheses.

描述(改编自申请的描述)：古斯塔夫森博士是一名 致力于在应用神经生理学领域建立职业生涯的工程师 神经功能恢复假体的研究与开发 患有神经疾病的个体。他的短期职业目标是 在电生理实验技术方面打下坚实的基础， 神经假体、泌尿生殖解剖学和现代医学实践。 拟议的职业发展计划将培训古斯塔夫森博士1) 电生理实验技术与神经假体；2) 与泌尿生殖相关的解剖学、生理学和医学实践，以及 脊髓损伤(SCI)患者的康复问题 独立的职业发展和翻译研究。凯斯的导师 西部储备大学(CWRU)、MetroHealth医学中心(MHMC)和 克利夫兰功能性电刺激中心(FESC)将提供 培训和专业知识，并监督和支持古斯塔夫森博士的职业生涯 进步。这项研究和培训的现有合作性质 环境与项目的多学科性质相适应 古斯塔夫森博士在生物医学研究方面的职业目标。 除了授课指导和有组织的临床培训外，并行 对患有脊髓损伤的动物和人类的研究项目被整合到 职业发展计划。研究计划将调查潜在的 神经生理学参与控制大小便的使用 选择性电记录和刺激单个神经束 阴部神经。首先，单个阴部神经分支 让最有效的感觉到反射性膀胱收缩的开始， 取消反射性膀胱收缩并引发协调排尿 确认身份。第二，用一根神经选择性地控制这三种功能 将检查放置在阴部神经上的袖带。解剖身体 研究将与有限元建模相结合，以评估和改进 器件选择性。失去膀胱控制是一个严重的问题 患有神经障碍和脊髓损伤的个体；发展有效的， 外周放置神经假体将显著改善临床 这些人的选择。这份职业发展计划将建立 古斯塔夫森博士作为生物医学研究和 让他做好准备，领导神经假体开发的研究工作。