Career training in bladder control neural protheses

膀胱控制神经假体的职业培训

• 批准号: 6649204
• 负责人: Kenneth J. Gustafson
• 金额: $ 10.79万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649204
• 关键词: assistive device /technology; bioengineering /biomedical engineering; biomedical equipment development; cats; electronic stimulator; electrophysiology; human subject; medical implant science; nervous system prosthesis; patient oriented research; rehabilitation; spinal cord injury; urinary incontinence; urinary tract prosthesis

DESCRIPTION (Adapted from Application's Description): Dr. Gustafson is an engineer committed to establishing a career in applied neurophysiology research and development of neural prosthetic devices to restore function in individuals with neurological disorders. His short-term career goals are to develop solid foundations in electrophysiological experimental techniques, neural prostheses, genitourinary anatomy and current medical practices. The proposed career development plan will train Dr. Gustafson in 1) electrophysiological experimental techniques and neuroprostheses; 2) genitourinary-related anatomy, physiology and medical practices, and rehabilitative issues for individuals with spinal cord injury (SCI); and 3) independent career development and translational research. Mentors at Case Western Reserve University (CWRU), MetroHealth Medical Center (MHMC) and the Cleveland Functional Electrical Stimulation Center (FESC) will provide training and expertise, and monitor and support Dr. Gustafson's career advancement. The existing collaborative nature of this research and training environment is suited to the multi-disciplinary nature of the project and Dr. Gustafson's career goals in biomedical research. In addition to didactic instruction and structured clinical training, parallel research projects in both animals and humans with SCI are integrated into the career development plan. The research plan will investigate the underlying neurophysiology involved in control of continence and micturition using selective electrical recording and stimulation of individual nerve fascicles of the pudendal nerve. First, the individual pudendal nerve branches that allow the greatest efficacy to sense the onset of reflex bladder contractions, abolish reflex bladder contractions and elicit coordinated micturition will be identified. Second, selective control of these 3 functions with a single nerve cuff placed on the pudendal nerve will be examined. Anatomical cadaver studies and finite element modeling will be combined to evaluate and improve device selectivity. Loss of bladder control is a significant problem in individuals with neurological disorders and SCI; development of an effective, peripherally located neuroprosthesis would significantly improve clinical options for these individuals. This career development plan will establish Dr. Gustafson as an independent investigator in biomedical research and prepare him to lead research efforts in the development of neural prostheses.

描述（改编自应用程序的描述）：Gustafson博士是一名 致力于在应用神经生理学领域建立职业生涯的工程师 研究和开发神经修复装置，以恢复功能， 患有神经系统疾病的人。 他的短期职业目标是 奠定坚实的电生理实验技术基础， 神经假体、泌尿生殖系统解剖学和当前的医疗实践。 拟议的职业发展计划将在1） 电生理实验技术和神经假体; 2） 生殖器相关的解剖学，生理学和医疗实践，以及 脊髓损伤（SCI）患者的康复问题;以及3） 独立的职业发展和翻译研究。案例导师 西储大学（CWRU），MetroHealth医疗中心（MHMC）和 克利夫兰功能性电刺激中心（FESC）将提供 培训和专业知识，并监督和支持古斯塔夫森博士的职业生涯 进步。 这项研究和培训的现有协作性质 环境适合项目的多学科性质， 古斯塔夫森博士在生物医学研究方面的职业目标。 除了教学指导和结构化的临床培训外， 在动物和人类SCI的研究项目被整合到 职业发展计划。研究计划将调查潜在的 神经生理学参与控制排尿和排尿， 单个神经束的选择性电记录和刺激 阴部神经 首先，阴部神经的分支 允许最有效地感知反射性膀胱收缩的开始， 消除反射性膀胱收缩并引起协调排尿将是 鉴定第二，用一根神经选择性地控制这三种功能 将检查放置在阴部神经上的袖套。 解剖尸体 研究和有限元建模相结合，以评估和改善 器件选择性 膀胱控制的丧失是一个重要的问题， 患有神经系统疾病和SCI的人;开发有效的， 外周定位的神经假体将显著改善临床 这些人的选择。 本职业发展计划将建立 Gustafson博士作为生物医学研究的独立调查员， 使他准备好领导神经假体开发的研究工作。