Career training in bladder control neural protheses

膀胱控制神经假体的职业培训

• 批准号: 6946499
• 负责人: Kenneth J. Gustafson
• 金额: $ 11.02万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946499
• 关键词: assistive device /technology; bioengineering /biomedical engineering; biomedical equipment development; cats; electronic stimulator; electrophysiology; human subject; medical implant science; nervous system prosthesis; patient oriented research; rehabilitation; spinal cord injury; urinary incontinence; urinary tract prosthesis

DESCRIPTION (Adapted from Application's Description): Dr. Gustafson is an engineer committed to establishing a career in applied neurophysiology research and development of neural prosthetic devices to restore function in individuals with neurological disorders. His short-term career goals are to develop solid foundations in electrophysiological experimental techniques, neural prostheses, genitourinary anatomy and current medical practices. The proposed career development plan will train Dr. Gustafson in 1) electrophysiological experimental techniques and neuroprostheses; 2) genitourinary-related anatomy, physiology and medical practices, and rehabilitative issues for individuals with spinal cord injury (SCI); and 3) independent career development and translational research. Mentors at Case Western Reserve University (CWRU), MetroHealth Medical Center (MHMC) and the Cleveland Functional Electrical Stimulation Center (FESC) will provide training and expertise, and monitor and support Dr. Gustafson's career advancement. The existing collaborative nature of this research and training environment is suited to the multi-disciplinary nature of the project and Dr. Gustafson's career goals in biomedical research. In addition to didactic instruction and structured clinical training, parallel research projects in both animals and humans with SCI are integrated into the career development plan. The research plan will investigate the underlying neurophysiology involved in control of continence and micturition using selective electrical recording and stimulation of individual nerve fascicles of the pudendal nerve. First, the individual pudendal nerve branches that allow the greatest efficacy to sense the onset of reflex bladder contractions, abolish reflex bladder contractions and elicit coordinated micturition will be identified. Second, selective control of these 3 functions with a single nerve cuff placed on the pudendal nerve will be examined. Anatomical cadaver studies and finite element modeling will be combined to evaluate and improve device selectivity. Loss of bladder control is a significant problem in individuals with neurological disorders and SCI; development of an effective, peripherally located neuroprosthesis would significantly improve clinical options for these individuals. This career development plan will establish Dr. Gustafson as an independent investigator in biomedical research and prepare him to lead research efforts in the development of neural prostheses.

描述（改编自应用程序描述）：古斯塔夫森博士是一名

项目成果

Linear performance characteristics of latissimus dorsi muscle: potential for cardiac assistance.

背阔肌的线性性能特征：心脏辅助的潜力。

• DOI: 10.1097/01.mat.0000084103.26533.19
• 发表时间: 2003
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Gustafson,KennethJ;Guilbeau,EricJ;Sweeney,JamesD
• 通讯作者: Sweeney,JamesD

Skeletal muscle ventricle pressure-volume properties conform to dynamic and static conditioning.

骨骼肌心室压力-容积特性符合动态和静态调节。

• DOI: 10.1016/s0003-4975(03)00513-7
• 发表时间: 2003
• 期刊: The Annals of thoracic surgery
• 作者: Gustafson,KennethJ;Sweeney,JamesD;Gibney,John;Fiebig-Mathine,LeeAnn
• 通讯作者: Fiebig-Mathine,LeeAnn

Is skeletal muscle ventricle chronic stability dependent on wall stress? Design implications.

骨骼肌心室的长期稳定性是否依赖于壁应力？

• DOI: 10.1111/j.1525-1594.2006.00177.x
• 发表时间: 2006
• 期刊: Artificial organs.
• 作者: Gustafson,KennethJ;Sweeney,JamesD;Gibney,John;Fiebig-Mathine,LeeAnn
• 通讯作者: Fiebig-Mathine,LeeAnn

Performance of dynamic and isovolumetric trained skeletal muscle ventricles.

动态和等容训练的骨骼肌心室的性能。

• DOI: 10.1016/j.jss.2006.02.054
• 发表时间: 2006
• 期刊: The Journal of surgical research.
• 作者: Gustafson,KennethJ;Sweeney,JamesD;Gibney,John;Fiebig-Mathine,LeeAnn
• 通讯作者: Fiebig-Mathine,LeeAnn