A randomised open-label study comparing the safety and efficacy of two alternative treatment options in the management of HIV-1 infected participants who have virologically failed a standard first-line combination ART regimen

一项随机开放标签研究，比较了两种替代治疗方案在管理 HIV-1 感染者（病毒学上未能通过标准一线联合 ART 方案）的安全性和有效性

• 批准号: nhmrc : 1042313
• 负责人: A/Pr Jintanat Ananworanich
• 金额: $ 30.52万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/randomised-open-label-art-regimen/111454
• 关键词: randomised; open; label; study; comparing

For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.

在过去十年中，国际社会作出了前所未有的努力，使所有艾滋病毒感染者都能获得护理，这是一项基本人权。这些人中的大多数人都接受了简单的药物组合治疗，这些药物被证明可以控制艾滋病毒。然而，当这种第一种药物组合停止工作时该怎么办是未知的。这项研究旨在填补这一知识空白，以便为第一种药物组合失败的患者提供第二种组合，以获得最大的成功机会。