A randomised open-label study comparing the safety and efficacy of two alternative treatment options in the management of HIV-1 infected participants who have virologically failed a standard first-line combination ART regimen

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For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.