权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Device for Enrichment of Skeletal Stem Cells for Orthopaedic Applications

用于骨科应用的骨骼干细胞富集装置

基本信息

批准号：
TS/G001650/1
负责人：
Richard Oreffo
金额：
$ 50.32万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=TS%2FG001650%2F1
关键词：
Device Enrichment Skeletal Stem Cells

项目摘要

With an increasing ageing population, strategies that allow the simple repair and augmentation of bone tissue, lost as a consequence of trauma or disease or with ageing, are urgently needed.The ability to develop a device that would allow the simple enrichment of skeletal stem cells from the bone marrow of a patient for orthopaedic application is thus an unmet and urgently required clinical target. This project proposes to progress the development of a unique and patented cell separation technology, developed by Smith and Nephew into a clinically effective and commercially viable surgical device. The implications for orthopaedic use are immense and potential for improving the quality of life in an increasing ageing population significant.This novel technology has the potential to transform orthopaedic clinical practice by increasing the accessibility of enriched autologous marrow. The Southampton group, includes clinicians and basic scientists, that will evaluate the device using human bone marrow samples and, through experimental studies aid in the evaluation and, if necessary, additional development of the cell separation device. The ability of the device to enrich for skeletal stem cells will be assessed by a battery of assays as well as unique models of bone formation available within Southampton.The collaboration between academic, industrial and clinical researchers will allow rapid development of the cell enrichment device and, critically, evaluation with human tissue to include pre-clinical study. This will allow us, within a 2 year time frame, to significantly contribute in Southampton to the programme of work from S&N to the generation of the regulatory data needed to allow clinical use of the proposed device.

随着人口老龄化的增加，迫切需要能够简单修复和增加由于创伤或疾病或衰老而丢失的骨组织的策略，因此，开发能够简单富集来自患者骨髓的骨骼干细胞用于骨科应用的装置的能力是未满足的和迫切需要的临床目标。本项目拟推进Smith and Nephew开发的独特专利细胞分离技术的开发，使其成为临床有效且商业上可行的手术器械。对骨科应用的影响是巨大的，并有可能改善日益老龄化人口的生活质量显着。这种新技术有可能通过增加富集自体骨髓的可及性来改变骨科临床实践。南安普顿小组包括临床医生和基础科学家，他们将使用人类骨髓样本对该设备进行评估，并通过实验研究帮助评估，如果必要的话，还将进一步开发细胞分离设备。该设备富集骨骼干细胞的能力将通过一系列检测以及南安普顿内可用的独特骨形成模型进行评估。学术界、工业界和临床研究人员之间的合作将使细胞富集设备的快速发展成为可能，关键是，用人体组织进行评估，包括临床前研究。这将使我们能够在2年的时间范围内，在南安普顿为S&N的工作计划做出重大贡献，以生成允许申报器械临床使用所需的监管数据。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ENRICHMENT OF SKELETAL STEM CELLS FROM BONE MARROW TO ENHANCE SKELETAL REGENERATION - A NOVEL CLINICAL TECHNIQUE

富集骨髓中的骨骼干细胞以增强骨骼再生——一种新颖的临床技术

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Alex Aarvold
通讯作者：
Alex Aarvold

A clinical strategy to concentrate aspirated bone marrow for skeletal stem cells to enhance skeletal regeneration

浓缩抽吸骨髓用于骨骼干细胞以增强骨骼再生的临床策略

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Alex Aarvold
通讯作者：
Alex Aarvold

A tissue engineering strategy for the treatment of avascular necrosis of the femoral head.

DOI：
10.1016/j.surge.2013.02.008
发表时间：
2013-12
期刊：
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
影响因子：
2.5
作者：
Aarvold, A.;Smith, J. O.;Tayton, E. R.;Jones, A. M. H.;Dawson, J. I.;Lanham, S.;Briscoe, A.;Dunlop, D. G.;Oreffo, R. O. C.
通讯作者：
Oreffo, R. O. C.

Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.

将组织工程原理带入临床：临床转化病例的检索分析。