Total Synthesis of Bioactive Natural Products

生物活性天然产物的全合成

• 批准号: 6328165
• 负责人: EMMANUEL A THEODORAKIS
• 金额: $ 22.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6328165
• 关键词: angiogenesis inhibitors; antineoplastics; carboxylation; chemical addition; chemical synthesis; cyclopentane; diterpenes; drug design /synthesis /production; macrolide antibiotics; quinones; reverse transcriptase inhibitors; sesquiterpenes

DESCRIPTION: (Applicant's Description) The first objective of this proposal is to study a novel methodology that allows access to substituted quinones and evaluate its scope and limitations during the synthesis of bioactive natural products, such as ilimaquinone avarone and avarol. The second objective of this proposal is the synthesis of norrisolide, a natural product for which in vivo studies have demonstrated that it causes irreversible vesiculation of the Golgi complex. A third objective of our research is the synthesis of borrelidin, an unusual macrolide with a very potent profile as an angiogenesis inhibitor.

描述：（申请人描述）本提案的第一个目标是