Total Synthesis of Bioactive Natural Products

描述：(申请人的描述)这项建议的第一个目标是 研究一种新的方法，允许获得取代的苯二酚和 评价其在生物活性天然产物合成中的应用范围和局限性 产品，如苯丙喹酮、阿凡诺等。这方面的第二个目标 建议合成去甲内酯，这是一种天然产品，对其在体内 研究表明，它会导致高尔基体不可逆的囊泡形成。 很复杂。我们研究的第三个目标是合成冬凌草素，一种 非同寻常的大环内酯类化合物，具有非常强的血管生成抑制作用。

DESCRIPTION: (Applicant's Description) The first objective of this proposal is to study a novel methodology that allows access to substituted quinones and evaluate its scope and limitations during the synthesis of bioactive natural products, such as ilimaquinone avarone and avarol. The second objective of this proposal is the synthesis of norrisolide, a natural product for which in vivo studies have demonstrated that it causes irreversible vesiculation of the Golgi complex. A third objective of our research is the synthesis of borrelidin, an unusual macrolide with a very potent profile as an angiogenesis inhibitor.