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Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
生物活性天然产物的全合成
批准号：
6633710
负责人：
EMMANUEL A THEODORAKIS
金额：
$20.01万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-01 至 2006-02-28
来源：
https://reporter.nih.gov/project-details/6633710
关键词：
angiogenesis inhibitors antineoplastics carboxylation chemical addition chemical synthesis cyclopentane diterpenes drug design /synthesis /production macrolide antibiotics quinones reverse transcriptase inhibitors sesquiterpenes

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英文摘要
DESCRIPTION: (Applicant's Description) The first objective of this proposal is to study a novel methodology that allows access to substituted quinones and evaluate its scope and limitations during the synthesis of bioactive natural products, such as ilimaquinone avarone and avarol. The second objective of this proposal is the synthesis of norrisolide, a natural product for which in vivo studies have demonstrated that it causes irreversible vesiculation of the Golgi complex. A third objective of our research is the synthesis of borrelidin, an unusual macrolide with a very potent profile as an angiogenesis inhibitor.
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