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THE S. CEREVISIAE S PHASE CHECKPOINT

THE S. CEREVISIAE S PHASE CHECKPOINT
酿酒酵母 S 阶段检查点
批准号：
6377773
负责人：
Steven I Reed
金额：
$26.6万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-09-30 至 2004-09-29
来源：
https://reporter.nih.gov/project-details/6377773
关键词：
DNA binding protein DNA repair DNA replication Saccharomyces cerevisiae cell growth regulation fungal genetics fungal proteins gene mutation microorganism culture molecular cloning phosphoproteins phosphorylation protein structure function

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英文摘要
DESCRIPTION: (Adapted from the Investigator's Abstract). This proposal will use a yeast model system to explore a checkpoint that coordinates completion of DNA replication with mitosis. Specifically, this proposal will investigate how a yeast cell, sensing that replication is not yet complete, blocks the transition from metaphase to anaphase. The importance of this checkpoint is obvious, in that entry into the process of cell division prior to duplication of the genetic material is a catastrophic event, leading to instantaneous loss of genomic integrity. The proposal focuses on several conserved proteins that were identified through genetic analysis, some of which previously had not been associated with checkpoint functions. The specific aims are to characterize the parameters of a "late" S phase checkpoint that depends on Pds1 to delay anaphase, to investigate the role of Rad23 and Ddi1 in the Pds1-dependent S phase checkpoint and to engage in a detailed structure/function analysis of the Rad23 and Ddi1 proteins.
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