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Imaging brain oxygen metabolism in health and disease

对健康和疾病中的脑氧代谢进行成像

基本信息

批准号：
1498828
负责人：
金额：
--
依托单位：
CARDIFF UNIVERSITY
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1498828
关键词：
Imaging brain oxygen metabolism health

项目摘要

Plasticity is a crucially important property of the brain for patients with multiple sclerosis (MS) as it underpins both spontaneous and rehabilitation driven functional recovery. Evidence suggests that brain plasticity may be hampered by tissue energy failure that is associated with MS inflammation and this may limit the potential for functional recovery. This project investigates (i) the effect of inflammation on brain energy metabolism in MS, under the hypothesis that inflammation leads to energy failure, and (ii) the relationship between inflammation-related energy failure and brain plasticity, anticipating that greater levels of inflammation-related energy failure correlate with more inefficient or insufficient plasticity. To assess the effect of inflammation on brain energetics and the relationship between brain energy failure and plasticity, we propose to study MS patients and matched healthy volunteers using advanced, non-invasive neuroimaging methods at Cardiff University Brain Research Imaging Centre (CUBRIC). Functional and structural alterations in the brain before and after a period of motor training will be examined. New functional imaging measures based on MRI assessment of the rate of cerebral metabolic oxygen consumption will be employed; structural measures will be quantified with myelin-sensitive MRI methods on CUBRIC's research-dedicated 3T MRI scanner.The project would demonstrate the value of new imaging markers of energetic function in MS and suggest new therapeutic targets centred around preventing or reversing energy failure and promoting brain plasticity.

对于多发性硬化症(MS)患者来说，可塑性是大脑的一个至关重要的属性，因为它支持自发和康复驱动的功能恢复。有证据表明，与多发性硬化症炎症相关的组织能量衰竭可能会阻碍大脑的可塑性，这可能会限制功能恢复的潜力。该项目研究(I)在炎症导致能量衰竭的假设下，炎症对多发性硬化症患者大脑能量代谢的影响，以及(Ii)炎症相关能量衰竭与大脑可塑性之间的关系，预计炎症相关能量衰竭的水平越高，可塑性越低或不足。为了评估炎症对脑能学的影响以及脑能量衰竭与可塑性之间的关系，我们建议在卡迪夫大学脑研究成像中心(Cubric)使用先进的非侵入性神经成像方法对多发性硬化症患者和匹配的健康志愿者进行研究。一段时间的运动训练前后大脑的功能和结构变化将被检查。将采用基于核磁共振对大脑代谢耗氧率进行评估的新的功能成像方法；将在Cubric的研究专用3T核磁共振扫描仪上用髓鞘敏感的核磁共振方法对结构测量进行量化。该项目将展示多发性硬化症能量功能的新成像标记物的价值，并建议以防止或逆转能量衰竭和促进大脑可塑性为中心的新治疗靶点。