PRECISE MRI DIRECTED SONIC ABLATION OF PROSTATE CANCER

描述：（申请人的描述） 拟议研究的总体目标是开发施用器 为了将高强度超声精确地传送到前列腺区域 包含癌症，同时实时热监测 前列腺和前列腺周围组织。该项目代表了一个合作 努力使高强度施加器适合于经尿道和 填隙使用将在位于旧金山的加州大学制造 弗朗西斯科，然后在体外和体内MRI研究中进行测试， 斯坦福大学的研究人员。三种类型的导管适用于 经尿道使用，它们的声聚焦程度不同， 在体外研究中设计、制造和测试，这些研究将 确定最有前途的设计实用前列腺消融。 评估标准将包括可能的加热速度， 执行加热到期望区域的适形递送，并且易于使用。的 最有前途的设计或设计将在犬体内进行测试 使用相敏成像的MR/温度测量的动物模型。相关 热电偶测量将在这些研究中进行，并实时 斯坦福大学开发的温度测量重建和显示系统将 适于前列腺的热标测。在体组织学研究 将对前列腺和前列腺周围组织进行超声处理， 与相位敏感、T2加权和对比增强MR图像相关， 确定成像前列腺组织坏死的最有效程序 直接用MRI。

DESCRIPTION: (Applicant's Description) The overall goal of the proposed research is the development of applicators for precise delivery of high intensity ultrasound to regions of the prostate containing cancer, with concurrent real-time thermal monitoring of the prostate and periprostatic tissues. The project represents a collaborative effort in which high-intensity applicators suitable for transurethral and interstitial use will be fabricated at University of California at San Francisco, and then tested in the in vitro and in vivo MRI studies by investigators at Stanford University. Three types of catheters suitable for transurethral use, differing in their degrees of acoustic focusing will be designed, fabricated and tested in the in vitro studies, these studies will determine the most promising design for practical prostate ablation. Evaluation criteria will include the speed of heating possible, the ability to perform conformal delivery of heating to desired regions, and ease of use. The most promising design or designs will then be tested in vive in a canine animal model with MR/ thermometry using phase-sensitive imaging. Correlative thermocouple measurements will be made during these studies, and a real-time thermometry reconstruction and display systems developed at Stanford will be adapted for thermal mapping of the prostate. Histologic studies of the in vive insonated prostatic and periprostatic tissues will be performed, and correlated to phase-sensitive, T2-weighted and contrast enhanced MR images, to determine the most effective procedure for imaging prostate tissue necrosis directly with MRI.