Precise MRI-Directed Sonic Ablation of Prostate Cancer

项目描述（由申请人提供）：该项目的长期目标是开发一种微创、有效、安全的前列腺癌治疗方法。我们的具体目标是：1)优化经尿道高强度超声用于前列腺消融的应用；2)在犬模型中严格评估应用器，包括研究磁共振引导消融的准确性和阐明长期（6周）超声前列腺的命运；3)评估磁共振引导经尿道高强度超声与经直肠HIFU相比用于靶向前列腺消融的相对优势和差异。4)评估我们的涂抹器在MRI引导下局部消融选定前列腺组织的能力，并证明患者的安全性。在美国，除皮肤癌外，前列腺癌是男性最常见的恶性肿瘤。我们目前正在开发的技术是为局部控制前列腺癌而设计的（即通过消融前列腺组织来控制原发性过程本身），由于高达88%的前列腺癌目前表现为器官局限性疾病，因此这些治疗方法将适用于大多数新出现的病例。聚焦超声是一种很有前途的技术，为下一代的非侵入性癌症治疗系统。利用这项技术，超声波能量被集中在身体深处的一个点上，以热消融目标组织。这可以通过皮肤或腔体表面的最小热沉积来完成，而无需穿刺或切口。这里提出的努力解决了使用经尿道聚焦超声治疗的主要技术挑战。应用器将被开发成对聚焦超声治疗与磁共振成像引导，以允许热能精确定位到目标组织。通过精确的温度测绘来监测前列腺目标区域的热沉积的技术将被开发出来，以确保整个目标体积都得到治疗，并确定关键结构，如直肠、神经血管束和尿道保持足够的凉爽，以避免损伤。新的涂抹器和系统将在体外和体内进行开发和评估。公共卫生相关性：我们将开发和测试一种综合系统，用于通过经尿道装置向前列腺输送高强度超声，在MRI热成像指导下，结合直肠和尿道冷却，控制前列腺癌的消融

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a minimally invasive, effective, and safe treatment for prostate cancer. Our specific aims are to 1) to optimize transurethral high intensity ultrasonic applicators for prostate ablation, 2) to rigorously evaluate the applicators in a canine model, including study of the accuracy of MR-guidance of ablation and elucidation of longer-term (6 weeks) fate of insonated prostate 3) to evaluate the relative advantages and differences of MR-guided transurethral high- intensity ultrasound compared to transrectal HIFU for targeted prostate ablation, 4) to evaluate the ability of our applicators to locally ablate selected prostate tissues under MRI guidance in human subjects with demonstrated patient safety. In the US, prostate cancer is the most common malignancy in men, excluding skin cancer. The techniques we are currently developing are designed for local control of prostate cancer (i.e., control of the primary process itself by ablation of prostatic tissues), and since up to 88% of prostate cancers are currently presenting as organ-confined disease, these therapies would thus be applicable to the majority of newly presenting cases. Focused ultrasound is a promising technique for the next generation of non- invasive cancer therapy systems. With this technology, ultrasound energy is focused at a point deep within the body to thermally ablate targeted tissue. This can be done with minimal heat deposition from the skin or cavity surface, without puncture or incision. The effort proposed here addresses the main technical challenges to using transurethral focused ultrasound therapy. The applicators will be developed to couple focused ultrasound treatment with Magnetic Resonance image guidance to allow precise targeting of the thermal energy to target tissues. Techniques to monitor heat deposition in targeted regions of the prostate gland, through accurate temperature mapping will be developed to insure that the entire target volume is being treated, and to ascertain that critical structures such as the rectum, the neurovascular bundles, and the urethra remain sufficiently cool to avoid damage. The new applicators and systems will be developed and evaluated both in vitro and in vivo. PUBLIC HEALTH RELEVANCE: We will develop and test an integrated system for the controlled ablation of prostate cancer using transurethral devices delivering high-intensity ultrasound to the prostate, directed by MRI thermal imaging, and incorporating rectal and urethral cooling