PRECISE MRI DIRECTED SONIC ABLATION OF PROSTATE CANCER

描述：(申请人描述) 拟议研究的总体目标是开发应用程序 用于将高强度超声准确地传送到前列腺区域 控制癌症，同时实时监测 前列腺癌和前列腺周组织。该项目代表着一个协作性的 高强度敷贴器适用于经尿路和 加州大学旧金山分校将制造间隙使用 Francisco，然后在体外和体内MRI研究中进行测试 斯坦福大学的调查人员。适用于三种类型的导管 经尿道使用，不同的声音聚焦程度将是 这些研究将在体外研究中设计、制造和测试 为实用的前列腺消融术确定最有希望的设计。 评估标准将包括可能的加热速度、 将供暖适形输送至所需区域，且易于使用。这个 最有希望的设计随后将在犬类身上进行活体测试。 动物模型的MR/相敏成像测温。相关 在这些研究期间将进行热电偶测量，并实时 斯坦福大学开发的测温重建和显示系统将是 适用于前列腺的热成像。活体组织学研究 将进行电离辐射的前列腺和前列腺周围组织手术，以及 与相位敏感、T2加权和对比度增强的MR图像相关 确定对前列腺组织坏死进行成像的最有效方法 直接用核磁共振检查。

DESCRIPTION: (Applicant's Description) The overall goal of the proposed research is the development of applicators for precise delivery of high intensity ultrasound to regions of the prostate containing cancer, with concurrent real-time thermal monitoring of the prostate and periprostatic tissues. The project represents a collaborative effort in which high-intensity applicators suitable for transurethral and interstitial use will be fabricated at University of California at San Francisco, and then tested in the in vitro and in vivo MRI studies by investigators at Stanford University. Three types of catheters suitable for transurethral use, differing in their degrees of acoustic focusing will be designed, fabricated and tested in the in vitro studies, these studies will determine the most promising design for practical prostate ablation. Evaluation criteria will include the speed of heating possible, the ability to perform conformal delivery of heating to desired regions, and ease of use. The most promising design or designs will then be tested in vive in a canine animal model with MR/ thermometry using phase-sensitive imaging. Correlative thermocouple measurements will be made during these studies, and a real-time thermometry reconstruction and display systems developed at Stanford will be adapted for thermal mapping of the prostate. Histologic studies of the in vive insonated prostatic and periprostatic tissues will be performed, and correlated to phase-sensitive, T2-weighted and contrast enhanced MR images, to determine the most effective procedure for imaging prostate tissue necrosis directly with MRI.