MR STUDY OF BRAIN INTERSTITIAL WATER MOTION

脑间质水运动的MR研究

• 批准号: 6391671
• 负责人: SHAO-POW P LIN
• 金额: $ 3.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6391671
• 关键词: acetazolamide; brain; brain metabolism; cerebrospinal fluid; cholera toxin; diffusion; interstitial; laboratory rat; magnetic resonance imaging; neuropharmacology; perfusion; polyethylene glycols; sodium ion

DESCRIPTION (Adapted from applicant's abstract): Brain water motion, which can be detected by MR techniques, varies depending on many factors, some characteristic of normal physiology and others of pathology. As a result, diffusion weighted imaging is used widely for the evaluation of a number of CNS states. Maintenance of water motion is either itself important for normal brain function or is at least an excellent marker of physiologic state. The Neil/Ackerman laboratory's research program focuses on elucidating the factors which determine water motion. This proposal focuses on learning more about the contribution of extracellular water to the total (intra- plus extracellular) water ADC. Motion in the interstitial fluid has contributions from bulk cerebrospinal fluid (CSF) flow, compartmental boundaries, and Brownian motion. Experiments were designed to determine the relative contribution of these three factors to ADC. The interstitial water ADC will be measured indirectly by measuring the motion of a broad range of extracellular markers. Recent results show that ADCs of compounds confined to the extracellular space are approximately equal despite marked differences in molecular weight (MW). This suggests that bulk CSF flow is a dominating factor. This idea will be tested with both large extracellular markers (polyethyleneglycols of MW=0.9 and 4 kD) and one very small marker (sodium, MW=23). Finally, CSF flow will be pharmacologically altered to directly assess its effect on extracellular water ADC.

描述（改编自申请人摘要）：脑水运动，其中