Pilot: Nicotine and exercise related energy expenditure in women

试点：尼古丁和女性运动相关的能量消耗

• 批准号: 6356245
• 负责人: DOUGLAS E JORENBY
• 金额: $ 5.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356245
• 关键词: behavioral /social science research tag; bioenergetics; calorimetry; clinical research; exercise; female; human subject; human therapy evaluation; nicotine replacement; relapse /recurrence; smoking cessation; substance abuse related behavior; weight control

DESCRIPTION: (Applicant's Description) On average, smokers weigh less than nonsmokers, and most smokers gain 2-3 kg of weight in the first six months of a cessation attempt. Fear of weight gain is a significant barrier to cessation attempts, particularly among women who smoke as a weight control strategy. For all its clinical relevance, little is known about the metabolic mechanisms of post-cessation weight gain or strategies to prevent it, esp. in women. This study will utilize a human indirect calorimetry chamber to assess exercise-related energy expenditure in 20 pre-menopausal women who are regular smokers. Each will participate in a pre-cessation assessment of resting energy expenditure, response to 20 minutes of standardized light exercise, and recovery time from exercise. The entire sample will then quit smoking for 72 hours, half using a 21 mg patch, half without nicotine replacement, and repeat the calorimetry assessment. The results should indicate the degree to which nicotine replacement therapy can increase exercise-related energy expenditure and/or prolong metabolic recovery time. Providing women with an active intervention to address weight gain may increase the number of successful cessation attempts, and may aid those who relapse due to fear of weight gain.

产品说明：平均而言，吸烟者的体重低于非吸烟者，大多数吸烟者在戒烟尝试的前六个月内体重增加2-3 kg。对体重增加的恐惧是戒烟尝试的一个重要障碍，特别是在吸烟作为体重控制策略的女性中。对于所有的临床相关性，人们对戒烟后体重增加的代谢机制或预防策略知之甚少，特别是在女性中。这项研究将利用人体间接测热室来评估20名绝经前经常吸烟的妇女的运动相关能量消耗。每个人都将参与停止前的静息能量消耗评估，对20分钟标准化轻度运动的反应，以及运动恢复时间。然后，整个样本将戒烟72小时，一半使用21 mg贴片，一半不使用尼古丁替代品，并重复热量测定评估。结果应表明尼古丁替代疗法可增加运动相关能量消耗和/或延长代谢恢复时间的程度。为女性提供积极的干预措施来解决体重增加可能会增加成功戒烟尝试的数量，并可能帮助那些由于害怕体重增加而复发的人。