Pilot: Nicotine and exercise related energy expenditure in women

描述：(申请者描述)平均而言，吸烟者的体重比不吸烟者轻，大多数吸烟者在戒烟尝试的前六个月增加了2-3公斤的体重。对体重增加的恐惧是戒烟尝试的一个重大障碍，特别是在吸烟作为体重控制策略的女性中。尽管它与临床相关，但对停药后体重增加的代谢机制或预防策略知之甚少，尤其是。在女人身上。这项研究将利用人体间接量热室来评估20名经常吸烟的绝经前女性与运动相关的能量消耗。每个人都将参与停止前的评估，包括静息能量消耗、对20分钟标准化轻度运动的反应以及运动恢复时间。然后，整个样本将戒烟72小时，其中一半使用21毫克的贴片，一半不使用尼古丁替代，并重复热量测量评估。结果应该表明尼古丁替代疗法可以在多大程度上增加运动相关的能量消耗和/或延长代谢恢复时间。为女性提供积极的干预措施以解决体重增加问题，可能会增加成功戒烟的次数，并可能帮助那些因害怕体重增加而复发的人。

DESCRIPTION: (Applicant's Description) On average, smokers weigh less than nonsmokers, and most smokers gain 2-3 kg of weight in the first six months of a cessation attempt. Fear of weight gain is a significant barrier to cessation attempts, particularly among women who smoke as a weight control strategy. For all its clinical relevance, little is known about the metabolic mechanisms of post-cessation weight gain or strategies to prevent it, esp. in women. This study will utilize a human indirect calorimetry chamber to assess exercise-related energy expenditure in 20 pre-menopausal women who are regular smokers. Each will participate in a pre-cessation assessment of resting energy expenditure, response to 20 minutes of standardized light exercise, and recovery time from exercise. The entire sample will then quit smoking for 72 hours, half using a 21 mg patch, half without nicotine replacement, and repeat the calorimetry assessment. The results should indicate the degree to which nicotine replacement therapy can increase exercise-related energy expenditure and/or prolong metabolic recovery time. Providing women with an active intervention to address weight gain may increase the number of successful cessation attempts, and may aid those who relapse due to fear of weight gain.