Core--Developmental Research

核心--发展研究

• 批准号: 7491739
• 负责人: DOUGLAS E JORENBY
• 金额: $ 1.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491739
• 关键词: Affective; Alcohols; Biological; Bupropion; Clinical Trials; Comorbidity; Development; Discipline; Drug Addiction; Fright; Individual; Measures; Mediator of activation protein; Medical; Methodology; Neuraxis; Patient Self-Report; Patients; Persons; Placebo Control; Population; Primary Health Care; Randomized; Randomized Clinical Trials; Recovery; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Research Proposals; Scientist; Site; Smoke; Smoker; Source; Tobacco Control Research; Tobacco Dependence; Transdisciplinary Tobacco Research Center; Treatment Efficacy; Treatment outcome; Underserved Population; United States National Institutes of Health; Work; affective neuroscience; conditioned fear; effectiveness trial; emotion regulation; innovation; interdisciplinary collaboration; novel; programs; research study; response; skills; success; tobacco control; volunteer

The specific aims of the UW TTURC's Developmental Research Core are to: (1) encourage high quality, innovative tobacco control research; (2) encourage investigators who have not previously worked in the tobacco control realm to engage in transdisciplinary collaborations, and (3) amplify the transdisciplinary research activities of the UW TTURC by expanding research opportunities in the four core studies. Mechanisms are presented for actively soliciting and evaluating developmental research applications from a wide variety of sources and disciplines. For the first year, two developmental research studies are proposed that explore themes of tobacco dependence mechanisms, outcomes and treatment mediators highly relevant to the main research proposals. One study uses emerging affective neuroscience methodologies (instructed fear conditioning, fear-potentiated startle assessments) and biological measures to assess potential mediators of response to bupropion. This study has the potential to reveal treatment outcome predictors including mechanisms not available to self-report. The second study seeks to investigate the population of smokers that would be excluded from both classic randomized clinical trials and effectiveness trials: smokers with significant medical or psychiatric comorbidity (including alcohol and/or other drug dependence). Three hundred such individuals will be recruited for a placebo-controlled treatment study that will assess the treatment success in this underserved population. This study will not only provide important estimates of treatment outcomes in an often-overlooked and under-served population, but will also provide novel information on predictors and mediators of treatment response that may be compared with those found in highly motivated volunteers and primary care patients who smoke.

UW TTURC发展研究核心的具体目标是：(1)鼓励高质量，创新的烟草控制研究；(2)鼓励以前没有从事烟草控制领域工作的研究人员进行跨学科合作；(3)通过扩大四个核心研究的研究机会，扩大西澳大学烟草研究中心的跨学科研究活动。提出了积极征求和评估来自各种来源和学科的发展研究应用的机制。在第一年，提出了两项发展研究，探讨与主要研究建议高度相关的烟草依赖机制、结果和治疗介质的主题。一项研究使用新兴的情感神经科学方法（指示恐惧条件反射，恐惧增强惊吓评估）和生物学测量来评估对安非他酮反应的潜在介质。这项研究有可能揭示治疗结果的预测因素，包括自我报告无法获得的机制。第二项研究旨在调查将被排除在两种经典之外的吸烟者群体