A Pilot Adherence Intervention for HIV-Infected Youth

针对艾滋病毒感染青少年的试点依从性干预措施

• 批准号: 6405626
• 负责人: Sybil Hosek
• 金额: $ 3.61万
• 依托单位: JOHN H. STROGER JR. HOSPITAL OF COOK COUNTY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-11-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6405626
• 关键词: AIDS; AIDS therapy; HIV infections; adolescence (12-20); antiviral agents; behavioral /social science research tag; clinical depression; clinical research; clinical trials; cognitive behavior therapy; combination chemotherapy; coping; health behavior; human subject; human therapy evaluation; outcomes research; patient care management; psychological stressor; psychological tests; questionnaires; substance abuse related disorder; therapy compliance; young adult human (21-34)

As the numbers of adolescents and young adults with HIV continue to increase, it becomes important to develop medication adherence interventions for a group with historically low rates of adherence. Among adults living with HIV, one of the most consistently significant predictors of medication non-adherence has been depression or the presence of depressive symptomatology (Singh et al., 1996; Chesney et al., 1996). Depression has also been found to be a significant predictor of medication non-adherence among HIV-positive adolescents (Hosek, 2000). This research project aims to expand the existing HIV adherence literature by exploring the feasibility, acceptability, and effectiveness of a cognitive-behavioral depression/coping skills intervention in increasing medication adherence among HIV-infected youth. Adolescents and young adults infected with HIV will be recruited from a large midwestern public medical facility and randomly assigned to either the intervention group or the standard-care comparison group. The results from this project are important in the development and implementation of larger interventions aimed at increasing medication adherence within this population.

随着感染艾滋病毒的青少年和年轻人的数量继续增加，为历史上依从率较低的群体制定药物依从性干预措施变得非常重要。在患有HIV的成年人中，药物不依从性的最一致的显著预测因素之一是抑郁症或抑郁性精神病的存在（Singh等人，1996; Chesney等人，1996年）。抑郁症也被发现是HIV阳性青少年不坚持服药的一个重要预测因素（Hosek，2000）。本研究项目旨在通过探讨认知行为抑郁/应对技能干预在增加艾滋病毒感染青年药物依从性方面的可行性、可接受性和有效性，来扩展现有的艾滋病毒依从性文献。感染艾滋病毒的青少年和年轻人将从中西部一家大型公共医疗机构招募，并随机分配到干预组或标准护理对照组。该项目的结果对于制定和实施更大的干预措施以提高这一人群的药物依从性非常重要。