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A multi-disciplinary approach to understanding the mechanisms that limit exercise tolerance

采用多学科方法来了解限制运动耐量的机制

基本信息

批准号：
1775136
负责人：
金额：
--
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1775136
关键词：
multi disciplinary approach understanding mechanisms

项目摘要

Background: Exercise tolerance is the strongest predictor of mortality and an important determinant of quality of life across the lifecourse. However, the mechanisms that limit exercise tolerance, and how these are altered with training are poorly understood.We have recently developed an exercise testing protocol (BB/100162X/1) that provides insight into the underpinning mechanisms that limit exercise tolerance. Furthermore, we have shown that during exercise we can systematically alter the stress on the different physiological systems that support exercise to different degrees (BB/100162X/1), and understand the systems interaction using a computational model of oxygen uptake and circulatory dynamics (BB/100162X/1). Objectives: To determine the influence of different physiological stresses on improvements in exercise tolerance and the mechanisms that underpin this improvement in function. Novelty: This will combine novel experimental and computational techniques to investigate for the first time how the mechanisms that limit exercise tolerance are differentially altered by divergent physiological stresses.Timeliness: New insight into the mechanisms that limit exercise tolerance will provide therapeutic targets that can be exploited in the future to promote healthy ageing, and reduce health care costs associated with poor exercise tolerance. These costs represent a current and growing burden on health care resources. Experimental approach: Using novel techniques developed in our labs, exercise tests will be used to measure exercise tolerance, and identify the underpinning mechanisms of the exercise limitation. Other key markers of physiological function will also be measured. These data will be used to explore the complex systems integration that limit exercise tolerance across the lifespan. Training studies will then be used to explore how the mechanisms that limit exercise tolerance respond to different physiological stresses. Again, these data will be used in combination with our computational model to understand the physiological drivers that promote specific adaptations with training.

背景：运动耐量是死亡率最强的预测因子，也是整个生命过程中生活质量的重要决定因素。然而，限制运动耐量的机制，以及如何改变这些与training.We最近开发了一个运动测试协议（BB/100162 X/1），提供了深入了解的基础机制，限制运动耐量。此外，我们已经证明，在运动过程中，我们可以系统地改变不同生理系统的压力，支持不同程度的运动（BB/100162 X/1），并使用氧摄取和循环动力学的计算模型来理解系统的相互作用（BB/100162 X/1）。目的：确定不同生理应激对运动耐量改善的影响以及支持这种功能改善的机制。新奇：这将结合联合收割机新的实验和计算技术，调查的机制，限制运动耐量的第一次不同的生理stresss.Timeliness改变：新的见解限制运动耐量的机制将提供治疗目标，可以利用在未来促进健康老龄化，并减少与运动耐量差的医疗保健费用。这些费用是目前卫生保健资源日益沉重的负担。实验方法：使用我们实验室开发的新技术，运动试验将用于测量运动耐量，并确定运动限制的基础机制。还将测量生理功能的其他关键标志物。这些数据将用于探索在整个生命周期中限制运动耐量的复杂系统集成。然后，训练研究将用于探索限制运动耐量的机制如何应对不同的生理压力。同样，这些数据将与我们的计算模型结合使用，以了解通过训练促进特定适应的生理驱动因素。