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Sweetening Drug Delivery for Future Therapies: Hydrogels Based on Sugars for Biomedical Applications

未来治疗的甜味剂药物输送：用于生物医学应用的基于糖的水凝胶

基本信息

批准号：
1777178
负责人：
金额：
--
依托单位：
University of East Anglia
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1777178
关键词：
Sweetening Drug Delivery Future Therapies

项目摘要

Hydrogels are 3D, cross-linked networks of water-soluble polymers, and formulated in a variety of physical forms (slabs, microparticles, nanoparticles...). Hydrogels show great promise in biomedical applications, drug delivery in particular, but also in clinical practice and experimental medicine for a wide range of applications (tissue engineering, regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells). Within the broad chemical family of "sugars", polysaccharides are excellent biopolymers for hydrogel preparation in biomedical contexts: they are non-toxic, water-soluble with high capability for swelling induced by simple chemical modifications, and they can be biodegraded to nontoxic products that are easily assimilated by the body. Great advances in polymer preparation for hydrogels (enzymatic procedures, nanocomposites, etc.) needs to be followed by an understanding at molecular level of the processes of gelation, the role of water, and the impact on final performance. In this project we will use state-of-the-art NMR spectroscopy (solution, solid, and gel state advanced experiments) to deepen our understanding of the molecular details of novel hydrogel materials based on starch and nanocellulose fibres. We will use cutting-edge glycobiology techniques (enzymatic and click chemistry) for functionalisation of nanocrystalline cellulose, prepare advanced materials (nanocomposite and interpenetrating network hydrogels), and will develop novel NMR spectroscopic protocols to understand the structure and dynamics of the biomaterials.

水凝胶是水溶性聚合物的3D交联网络，并以各种物理形式（平板，微粒，纳米颗粒......）配制。水凝胶在生物医学应用中显示出巨大的前景，特别是药物递送，而且在临床实践和实验医学中用于广泛的应用（组织工程、再生医学、诊断、细胞固定、生物分子或细胞的分离）。在“糖”的广泛化学家族中，多糖是用于生物医学背景下的水凝胶制备的优异生物聚合物：它们是无毒的、水溶性的，具有由简单化学修饰诱导的高溶胀能力，并且它们可以生物降解成易于被身体吸收的无毒产物。水凝胶用聚合物制备的巨大进步（酶法、纳米复合材料等）需要在分子水平上理解凝胶化过程、水的作用以及对最终性能的影响。在这个项目中，我们将使用最先进的NMR光谱（溶液，固体和凝胶状态高级实验）来加深我们对基于淀粉和纳米纤维素纤维的新型水凝胶材料的分子细节的理解。我们将使用尖端的糖生物学技术（酶和点击化学）对纳米晶纤维素进行功能化，制备先进的材料（纳米复合材料和互穿网络水凝胶），并将开发新的NMR光谱协议，以了解生物材料的结构和动力学。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chemoenzymatic Synthesis of Fluorinated Cellodextrins Identifies a New Allomorph for Cellulose-Like Materials*.

DOI：
10.1002/chem.202003604
发表时间：
2021-01-18
期刊：
Chemistry (Weinheim an der Bergstrasse, Germany)
影响因子：
0
作者：
de Andrade P;Muñoz-García JC;Pergolizzi G;Gabrielli V;Nepogodiev SA;Iuga D;Fábián L;Nigmatullin R;Johns MA;Harniman R;Eichhorn SJ;Angulo J;Khimyak YZ;Field RA
通讯作者：
Field RA

Thermosensitive supramolecular and colloidal hydrogels via self-assembly modulated by hydrophobized cellulose nanocrystals