NEW YORK REGIONAL ISLET ISOLATION FACILITY

使用埃德蒙顿方案，通过移植用活胰岛替代无功能胰岛组织已被证明是有效的。考虑到人口众多和纽约大都会地区学术中心致力于治疗糖尿病，我们地区显然需要一个胰岛隔离中心，用于研究和临床移植。我们建议建立纽约地区胰岛资源中心，集中胰岛分离、纯化和分配，为超过2500万人提供服务。虽然该地区的几个机构已经有了糖尿病项目（哥伦比亚大学内科和外科学院，Mt.西奈医学院、阿尔伯特·爱因斯坦医学院和纽约威尔-康奈尔医学中心），除了哥伦比亚/威尔-康奈尔/纽约长老会医院外，没有其他项目开发了人类胰岛分离的专业知识。IRC将支持当前和未来的协议，利用合并后的纽约长老会医院（NYPH）教学医院的临床资源，以及外科，病理学，医学和分子生物学领域的临床医生和科学家的整合。胰岛资源中心，包括一个GMP级细胞治疗设施，将解决分离足够的胰岛质量，纯化和量化胰岛，开发改进的生存力，功能，质量控制/保证，银行和分配的问题和技术困难根据拟议的指导方针。

Replacement of non-functional islet tissue with viable pancreatic islets by transplantation has proven to be effective using the Edmonton Protocol. Given the large population and the dedication of academic centers in the New York Metropolitan area to treat diabetes, our region clearly needs an islet isolation center for the purposes of investigational and clinical transplantation. We propose the establishment of the New York Regional Islet Resource Center to centralize islet isolation, purification, and distribution in a region serving more than 25 million people. While several institutions in this region already have Program Projects in Diabetes (Columbia University College of Physician and Surgeons, Mt. Sinai Medical School, Albert Einstein College of Medicine, and New York Weill-Cornell Medical Center), no programs other than Columbia/Weill-Cornell/New York-Presbyterian Hospital have developed expertise in human islet isolation. The IRC will support current and future protocols, taking advantage of clinical resources of the merged teaching hospital of New York-Presbyterian Hospital (NYPH) and the integration of the clinicians and scientists in the fields of surgery, pathology, medicine, and molecular biology. The Islet Resource Center, including a GMP grade Cell Therapy Facility, will address the issues and technical difficulties of isolating a sufficient islet mass, purifying and quantifying islets, developing improved markers of viability, function, quality control/assurance, banking and distribution according to proposed guidelines.