NEW YORK REGIONAL ISLET ISOLATION FACILITY

用有活力的胰岛移植替代无功能的胰岛组织已被证明是有效的使用埃德蒙顿协议。考虑到纽约大都会区人口众多，学术中心致力于治疗糖尿病，我们的地区显然需要一个胰岛隔离中心，用于研究和临床移植。我们建议建立纽约区域胰岛资源中心，在一个服务于2500多万人的地区集中进行胰岛的隔离、净化和分配。虽然该地区的一些机构已经有糖尿病项目（哥伦比亚大学内科和外科学院、西奈山医学院、阿尔伯特·爱因斯坦医学院和纽约威尔-康奈尔医学中心），但除了哥伦比亚/威尔-康奈尔/纽约长老会医院之外，没有其他项目开发出人类胰岛分离的专业知识。IRC将利用纽约长老会医院（New York-Presbyterian hospital， NYPH）合并教学医院的临床资源，整合外科、病理学、医学和分子生物学领域的临床医生和科学家，支持当前和未来的方案。胰岛资源中心，包括一个GMP级细胞治疗设施，将解决问题和技术困难，分离足够的胰岛质量，净化和量化胰岛，根据拟议的指南开发改进的活力、功能、质量控制/保证、银行和分配标记。

Replacement of non-functional islet tissue with viable pancreatic islets by transplantation has proven to be effective using the Edmonton Protocol. Given the large population and the dedication of academic centers in the New York Metropolitan area to treat diabetes, our region clearly needs an islet isolation center for the purposes of investigational and clinical transplantation. We propose the establishment of the New York Regional Islet Resource Center to centralize islet isolation, purification, and distribution in a region serving more than 25 million people. While several institutions in this region already have Program Projects in Diabetes (Columbia University College of Physician and Surgeons, Mt. Sinai Medical School, Albert Einstein College of Medicine, and New York Weill-Cornell Medical Center), no programs other than Columbia/Weill-Cornell/New York-Presbyterian Hospital have developed expertise in human islet isolation. The IRC will support current and future protocols, taking advantage of clinical resources of the merged teaching hospital of New York-Presbyterian Hospital (NYPH) and the integration of the clinicians and scientists in the fields of surgery, pathology, medicine, and molecular biology. The Islet Resource Center, including a GMP grade Cell Therapy Facility, will address the issues and technical difficulties of isolating a sufficient islet mass, purifying and quantifying islets, developing improved markers of viability, function, quality control/assurance, banking and distribution according to proposed guidelines.